Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650716 | 0.90 | JAK2 (0.38) | JAK2JAK3MAPK8MAPK10CDK9 | |
| SCHEMBL22650701 | 0.90 | JAK2 (0.38) | JAK2JAK3MAPK8MAPK10CDK9 | |
| SCHEMBL22650419 | 0.86 | JAK2 (0.38) | JAK2JAK3CDK9BRD4CDK1 | |
| SCHEMBL22650423 | 0.85 | JAK2 (0.37) | JAK2JAK3MAPK8MAPK10CDK9 | |
| SCHEMBL22650847 | 0.81 | JAK2 (0.39) | JAK2JAK3CDK9BRD4CDK1 | |
| SCHEMBL22650795 | 0.77 | CDK4 (0.41) | CDK9CDK1CDK4CCNB1CCND1 | |
| SCHEMBL22650709 | 0.75 | JAK2 (0.39) | JAK2JAK3CDK9BRD4CDK1 | |
| SCHEMBL22650707 | 0.75 | JAK2 (0.39) | JAK2JAK3CDK9BRD4CDK1 | |
| SCHEMBL22650536 | 0.74 | JAK2 (0.34) | JAK2JAK3CDK9BRD4CDK1 | |
| SCHEMBL22650599 | 0.72 | DKK1 (0.43) | MAPK8MAPK10CDK9CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |