Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | SMG1 | Q96Q15 | 6/20 | 0.42 |
| ▸ | MTOR | P42345 | 7/20 | 0.41 |
| ▸ | CDK1 | P06493 | 7/20 | 0.40 |
| ▸ | IKBKB | O14920 | 6/20 | 0.40 |
| ▸ | CDK2 | P24941 | 6/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650701 | 0.74 | JAK2 (0.38) | GSK3BCDK1CDK2MAPK8MAPK10 | |
| SCHEMBL22650918 | 0.73 | DKK1 (0.57) | DKK1GSK3BSMG1MTORCDK1 | |
| SCHEMBL22650716 | 0.73 | JAK2 (0.38) | CDK1MAPK8MAPK10CDK4CCNB1 | |
| SCHEMBL22650604 | 0.72 | JAK2 (0.37) | SMG1CDK1MAPK8MAPK10CDK4 | |
| SCHEMBL22650423 | 0.72 | JAK2 (0.37) | GSK3BCDK1IKBKBCDK2MAPK8 | |
| SCHEMBL22650930 | 0.69 | CDK4 (0.50) | CDK1CDK2CDK4CCNB1CCND1 | |
| SCHEMBL22650923 | 0.66 | MAPK8 (0.54) | GSK3BCDK1IKBKBCDK2MAPK8 | |
| SCHEMBL22650920 | 0.64 | CDK2 (0.54) | CDK1CDK2MAPK8MAPK10CDK4 | |
| SCHEMBL22650919 | 0.63 | CDK2 (0.54) | GSK3BCDK1CDK2MAPK8MAPK10 | |
| SCHEMBL3517290 | 0.63 | IKBKB (0.78) | DKK1GSK3BCDK1IKBKBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |