SCHEMBL22654071

SCHEMBL22654071

C=Cc1c(Cl)ccc(F)c1-c1c(OC(=O)C(C)C)c(C)nn(C)c1=O

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 2/20 0.31
TP53 P04637 1/20 0.31
GAA P10253 1/20 0.31
FPR2 P25090 1/20 0.31
PROKR1 Q8TCW9 1/20 0.31
HTT P42858 2/20 0.31
GALR3 O60755 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C19 P33261 1/20 0.31
NR2F2 P24468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29658208 1.00 SMN1; SMN2 (0.31) SMN1; SMN2LMNAMAPTTP53GAA
SCHEMBL22654074 0.95
SCHEMBL22031795 0.86 P2RX7 (0.33) SMN1; SMN2HTTGALR3CYP1A2CYP3A4
SCHEMBL22031793 0.85 MEN1 (0.33) SMN1; SMN2LMNAMAPTTP53GAA
SCHEMBL29457680 0.85 MEN1 (0.33) SMN1; SMN2LMNAMAPTTP53GAA
(Z)-1,2-Diphenylethene SCHEMBL29582372 0.83 TP53 (0.33) SMN1; SMN2LMNAMAPTTP53GAA
SCHEMBL27200156 0.82 P4HB (0.31) SMN1; SMN2GAA
SCHEMBL29658200 0.82 P4HB (0.31) SMN1; SMN2GAA
SCHEMBL22654069 0.82 FPR2 (0.31) FPR2PROKR1
SCHEMBL25184823 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12540120-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2026-02-03 US disclosed
CN-114555563-B Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-11-15 CN disclosed
CN-114144409-B Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-08-09 CN disclosed
CN-118108674-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-31 CN disclosed
CN-118084803-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-28 CN disclosed
CN-118084802-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-05-28 CN disclosed
CN-111566094-B herbicidal compounds 先正达参股股份有限公司 2023-10-13 CN disclosed
US-20220281827-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-09-08 US disclosed
CN-114555563-A Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2022-05-27 CN disclosed
EP-3999503-A1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2022-05-25 EP disclosed
EP-3999494-A2 SUBSTITUTED PYRIDAZINONES AS HERBICIDES Syngenta Crop Protection AG (CH) 2022-05-25 EP disclosed
WO-2021009334-A2 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed
WO-2021009334-A2 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed
WO-2021009335-A1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed
US-20210009530-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-01-14 US disclosed
EP-3737667-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2020-11-18 EP disclosed
CN-111566094-A Herbicidal compounds 先正达参股股份有限公司 2020-08-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210009530-A1 HERBICIDAL COMPOUNDS DDT, HPD, PGD SMN1; SMN2 4689/4885LMNA 2631/4885MAPT 3439/4885
US-20220281827-A1 HERBICIDAL COMPOUNDS DDT, HPD, PGD SMN1; SMN2 4689/4885LMNA 2631/4885MAPT 3439/4885
US-12540120-B2 Herbicidal compounds CBR3, CBR1, HACL2 SMN1; SMN2 4517/4885LMNA 1102/4885MAPT 4774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.