Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22515860 | 0.80 | HDAC3 (0.38) | HDAC3HDAC1HDAC2HDAC6ALOX5 | |
| SCHEMBL6299629 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AHDAC1TBXAS1 | |
| SCHEMBL4082326 | 0.75 | BCL2L1 (0.61) | SMN1; SMN2NPC1RAB9AHDAC1TBXAS1 | |
| SCHEMBL9612673 | 0.75 | DYRK1A (0.65) | SMN1; SMN2NPC1RAB9AHDAC1TBXAS1 | |
| SCHEMBL18936125 | 0.74 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9AHDAC1TBXAS1 | |
| SCHEMBL13201470 | 0.73 | TBXAS1 (0.56) | SMN1; SMN2NPC1RAB9AHDAC1GRIN2C | |
| SCHEMBL20887652 | 0.73 | CYP2A6 (0.50) | RAB9AALOX5CYP1A2LMNAPTGES | |
| SCHEMBL12294503 | 0.73 | RAB9A (0.43) | SMN1; SMN2NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL9612645 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL23612300 | 0.72 | ALDH1A1 (0.39) | SMN1; SMN2NPC1RAB9AKDM4EALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200361920-A1 | ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361920-A1 | ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | SLC10A1, NR1H4, SLC10A2 | SMN1; SMN2 4610/4885NPC1 71/4885RAB9A 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.