Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2267982 | 0.85 | SIGMAR1 (0.57) | ALDH1A1SMN1; SMN2HIF1AGAAHRH3 | |
| Trifluoroacetic Acid SCHEMBL2267986 | 0.85 | SIGMAR1 (0.57) | ALDH1A1SMN1; SMN2HIF1AGAAHRH3 | |
| SCHEMBL102338 | 0.85 | SIGMAR1 (0.71) | RAB9ANPC1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL6200777 | 0.85 | SIGMAR1 (0.71) | RAB9ANPC1HTTALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2269036 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HIF1AGAAHRH3TSHR | |
| SCHEMBL18065638 | 0.83 | SIGMAR1 (0.68) | KCNJ1RAB9ANPC1HTTALDH1A1 | |
| Water SCHEMBL1702298 | 0.83 | SIGMAR1 (0.68) | RAB9ANPC1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL948372 | 0.83 | SIGMAR1 (0.68) | KCNJ1RAB9ANPC1HTTALDH1A1 | |
| SCHEMBL896379 | 0.83 | SIGMAR1 (0.68) | KCNJ1RAB9ANPC1HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL6261135 | 0.83 | SIGMAR1 (0.68) | RAB9ANPC1HTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201657-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | PARP1, PARP3, PARP2 | KCNJ1 2288/4885RAB9A 3743/4885NPC1 4478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.