SCHEMBL2268166

SCHEMBL2268166

O=C(Cl)c1ccc(C(=O)Cl)c(Br)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
MBTD1 Q05BQ5 1/20 0.36
L3MBTL3 Q96JM7 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
TSHR P16473 2/20 0.36
TTR P02766 1/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
ALOX15 P16050 1/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 4/20 0.33
FLT1 P17948 2/20 0.33
FLT4 P35916 2/20 0.33
KDR P35968 2/20 0.33
RXRA P19793 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
NOTUM Q6P988 1/20 0.33
CA1 P00915 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2266803 0.83 MAPT (0.38) ALDH1A1TSHRTTRCES2CES1
SCHEMBL7683262 0.82 MAPT (0.40) ALDH1A1TSHRTTRCES2CES1
SCHEMBL5089887 0.81 KDM4E (0.49) ALDH1A1MAPTHPGDNOTUMCA1
SCHEMBL10882023 0.80 ALDH1A1 (0.38) ALDH1A1TSHRTTRCES2CES1
SCHEMBL6862035 0.80 FLT1 (0.46) ALDH1A1L3MBTL1CES2ALOX15HPGD
SCHEMBL29440655 0.79 ALDH1A1 (0.40) ALDH1A1L3MBTL1TSHRCES2CES1
SCHEMBL75886 0.79 ALDH1A1 (0.40) ALDH1A1L3MBTL1TSHRCES2CES1
SCHEMBL4900937 0.78 ALOX15 (0.48) ALDH1A1L3MBTL1TTRCES2ALOX15
SCHEMBL2964948 0.78 TSHR (0.43) ALDH1A1TSHRMAPTKDR
SCHEMBL1164132 0.78 FLT1 (0.51) ALDH1A1TSHRMAPTHPGDFLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080203013-A1 OXIDATION-RESISTANT COMPOSITE REVERSE OSMOSIS MEMBRANE VONTRON MEMBRANE TECHNOLOGY CO., LTD. (CN) 2008-08-28 US claimed
WO-2008025259-A1 OXIDATION-RESISTANT COMPOSITE REVERSE OSMOSIS MEMBRANE VONTRON MEMBRANE TECHNOLOGY CO., LTD. (CN) 2008-03-06 WO claimed
EP-1894614-A1 Oxidation-resistant composite reverse osmosis membrane Vontron Membrane Technology Co Ltd (CN) 2008-03-05 EP claimed
US-20240116857-A1 QUATERNARY AMMONIUM COMPOUNDS AS ANTIMICROBIALS SAINT LOUIS UNIVERSITY (US) 2024-04-11 US disclosed
CN-109768320-B All-solid-state polymer electrolyte, preparation method thereof and all-solid-state lithium ion battery 南方科技大学 2021-05-07 CN disclosed
EP-2651917-A1 DIMERIC IAP INHIBITORS Novartis AG (CH) 2013-10-23 EP disclosed
US-20130266590-A1 DIMERIC IAP INHIBITORS NOVARTIS AG (CH) 2013-10-10 US disclosed
US-8445440-B2 Dimeric IAP inhibitors NOVARTIS AG (CH) 2013-05-21 US disclosed
EP-2539333-A1 DIMERIC IAP INHIBITORS Novartis AG (CH) 2013-01-02 EP disclosed
WO-2012080260-A1 DIMERIC IAP INHIBITORS NOVARTIS AG (CH) 2012-06-21 WO disclosed
WO-2011104266-A1 DIMERIC IAP INHIBITORS NOVARTIS AG (CH) 2011-09-01 WO disclosed
US-4565850-A Thermoplastic composition containing nematic oligomer ALLIED CORPORATION (US) 1986-01-21 US disclosed
US-4507465-A IMPACT STRENGTH TORAY INDUSTRIES, INC. (JP) 1985-03-26 US disclosed
EP-0113252-A2 Process for producing block copolyamide TORAY INDUSTRIES, INC. (JP) 1984-07-11 EP disclosed
EP-0071968-A1 Thermoplastic composition containing oligomer ALLIED CORPORATION (US) 1983-02-16 EP disclosed
US-4342862-A Polyesters of trans-1,4-cyclohexanedicarboxylic acid and 2-phenylhydroquinone and modifications thereof EASTMAN KODAK COMPANY (US) 1982-08-03 US disclosed
US-4101399-A Production of solvent resistant brominated and/or chlorinated aromatic polyester fibrous materials CELANESE CORPORATION (US) 1978-07-18 US disclosed
US-4024153-A ULTRAVIOLET STABILIZERS EASTMAN KODAK COMPANY (US) 1977-05-17 US disclosed
US-4001179-A Bis-(tetrahalophthalimidocarbonyl)-benzene VELSICOL CHEMICAL CORPORATION (US) 1977-01-04 US disclosed
US-3954706-A Polychromophoric benzotriazole ultraviolet stabilizers for organic compositions EASTMAN KODAK COMPANY (US) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130266590-A1 DIMERIC IAP INHIBITORS XIAP, BIRC5, BIRC2 ALDH1A1 4312/4885MBTD1 706/4885L3MBTL3 115/4885
US-20240116857-A1 QUATERNARY AMMONIUM COMPOUNDS AS ANTIMICROBIALS ABCC1, ARG1, SLC11A2 ALDH1A1 2841/4885MBTD1 2295/4885L3MBTL3 2486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.