SCHEMBL2269459

SCHEMBL2269459

CC(=O)Oc1ccc(C(=O)Nc2cc(-c3ccccc3)ccc2C(=O)O)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.63
KMT2A Q03164 4/20 0.63
ACLY P53396 3/20 0.60
DHODH Q02127 1/20 0.59
LMNA P02545 1/20 0.56
GAA P10253 1/20 0.56
IGF2BP2 Q9Y6M1 1/20 0.55
HSD17B10 Q99714 1/20 0.54
TDP1 Q9NUW8 2/20 0.53
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
MAPT P10636 1/20 0.53
PKM P14618 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
SERPINE1 P05121 1/20 0.52
HDAC2 Q92769 3/20 0.52
HDAC1 Q13547 2/20 0.52
GALK1 P51570 1/20 0.52
CASP6 P55212 1/20 0.52
MCL1 Q07820 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269365 0.90 MEN1 (0.60) MEN1KMT2AACLYDHODHLMNA
SCHEMBL2270661 0.88 ACLY (0.58) MEN1KMT2AACLYDHODHLMNA
SCHEMBL2269165 0.88 MEN1 (0.69) MEN1KMT2AACLYDHODHIGF2BP2
SCHEMBL2270222 0.87 DHODH (0.77) MEN1KMT2AACLYDHODHIGF2BP2
SCHEMBL2272774 0.85 KMT2A (0.63) MEN1KMT2ATDP1NPC1RAB9A
SCHEMBL3043771 0.85 KMT2A (0.61) MEN1KMT2ALMNAGAAIGF2BP2
SCHEMBL6359536 0.84 KMT2A (0.78) MEN1KMT2ADHODHNPC1RAB9A
SCHEMBL2275453 0.84 ACLY (0.76) MEN1KMT2AACLYDHODHTDP1
SCHEMBL2275393 0.84 HDAC2 (0.73) MEN1KMT2AACLYDHODHTDP1
SCHEMBL2269909 0.83 ACLY (0.67) MEN1KMT2AACLYDHODHTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885ACLY 653/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.