SCHEMBL2272774

SCHEMBL2272774

CC(=O)Oc1ccc(C(=O)Nc2cc(Oc3ccccc3)ccc2C(=O)O)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.63
MEN1 O00255 3/20 0.63
SERPINE1 P05121 1/20 0.58
NR1H4 Q96RI1 2/20 0.55
HPSE Q9Y251 1/20 0.54
NPSR1 Q6W5P4 2/20 0.53
PKM P14618 1/20 0.53
GALK1 P51570 1/20 0.52
CASP6 P55212 1/20 0.52
MCL1 Q07820 1/20 0.52
PLEC Q15149 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
POLB P06746 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
PYGL P06737 1/20 0.51
PYGM P11217 1/20 0.51
KCNK2 O95069 1/20 0.51
KCNK10 P57789 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274678 0.91 PYGM (0.57) KMT2AMEN1PKMSMN1; SMN2NPC1
SCHEMBL2271588 0.88 SERPINE1 (0.64) KMT2AMEN1SERPINE1NR1H4HPSE
SCHEMBL2271007 0.88 MEN1 (0.69) KMT2AMEN1SERPINE1NR1H4HPSE
SCHEMBL2275467 0.88 CYP2C9 (0.63) KMT2AMEN1SERPINE1NR1H4HPSE
SCHEMBL2276745 0.86 SERPINE1 (0.65) KMT2AMEN1SERPINE1NR1H4HPSE
SCHEMBL2270621 0.86 GALK1 (0.68) SERPINE1NR1H4HPSEGALK1CASP6
SCHEMBL2269459 0.85 MEN1 (0.63) KMT2AMEN1SERPINE1NPSR1PKM
SCHEMBL2272043 0.85 SERPINE1 (0.75) KMT2AMEN1SERPINE1NR1H4HPSE
SCHEMBL2273634 0.85 SERPINE1 (0.60) KMT2AMEN1SERPINE1NR1H4HPSE
SCHEMBL2276169 0.85 SERPINE1 (0.60) KMT2AMEN1SERPINE1NR1H4HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KMT2A 1669/4885MEN1 3105/4885SERPINE1 101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.