SCHEMBL2269847

SCHEMBL2269847

CC(C)(C)OC(=O)c1ccc(-c2ccc(Oc3ccccc3)cc2)cc1NC(=O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 6/20 0.52
HDAC1 Q13547 3/20 0.48
PGR P06401 2/20 0.48
HDAC3 O15379 1/20 0.47
FABP1 P07148 1/20 0.47
IGF2BP2 Q9Y6M1 1/20 0.47
GALK1 P51570 1/20 0.47
CASP6 P55212 1/20 0.47
MCL1 Q07820 1/20 0.47
PLEC Q15149 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
SERPINE1 P05121 1/20 0.46
ACLY P53396 1/20 0.46
NR1H4 Q96RI1 2/20 0.44
KDM4E B2RXH2 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275596 0.90 FABP1 (0.51) HDAC1PGRFABP1GALK1CASP6
SCHEMBL27716688 0.89 HDAC2 (0.50) HDAC2HDAC1PGRHDAC3FABP1
SCHEMBL2274754 0.88 HDAC2 (0.53) HDAC2HDAC1HDAC3IGF2BP2TDP1
SCHEMBL2273488 0.87 SUCNR1 (0.52) HDAC2HDAC1HDAC3SERPINE1ACLY
SCHEMBL2269139 0.86 CYP2C9 (0.47) HDAC2HDAC1PGRHDAC3SERPINE1
Cyanate SCHEMBL27830146 0.86 HDAC2 (0.51) HDAC2HDAC1HDAC3IGF2BP2ACLY
SCHEMBL12117883 0.86 MCL1 (0.43) HDAC1IGF2BP2GALK1CASP6MCL1
SCHEMBL1319258 0.86 HDAC1 (0.47) HDAC2HDAC1HDAC3IGF2BP2GALK1
SCHEMBL2269667 0.85 F10 (0.53) HDAC2HDAC1PGRHDAC3SERPINE1
SCHEMBL2276006 0.85 HDAC1 (0.48) HDAC2HDAC1HDAC3TDP1ACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 HDAC2 276/4885HDAC1 71/4885PGR 3411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.