SCHEMBL2274754

SCHEMBL2274754

CC(C)(C)OC(=O)c1ccc(-c2ccc(O)cc2)cc1NC(=O)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 8/20 0.53
HDAC1 Q13547 6/20 0.53
HDAC3 O15379 1/20 0.49
ACLY P53396 1/20 0.47
KDM4E B2RXH2 1/20 0.46
MAPK1 P28482 1/20 0.46
HSD17B10 Q99714 1/20 0.46
DEGS1 O15121 1/20 0.46
IGF2BP2 Q9Y6M1 1/20 0.46
DHODH Q02127 1/20 0.45
MEN1 O00255 1/20 0.45
MAPT P10636 1/20 0.45
PKM P14618 1/20 0.45
GRIK1 P39086 1/20 0.45
KMT2A Q03164 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
ELANE P08246 1/20 0.45
PRTN3 P24158 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273488 0.89 SUCNR1 (0.52) HDAC2HDAC1HDAC3ACLYMEN1
Cyanate SCHEMBL27830146 0.88 HDAC2 (0.51) HDAC2HDAC1HDAC3ACLYKDM4E
SCHEMBL2269847 0.88 HDAC2 (0.52) HDAC2HDAC1HDAC3ACLYKDM4E
SCHEMBL27848558 0.88 HDAC2 (0.51) HDAC2HDAC1HDAC3ACLYKDM4E
SCHEMBL2276006 0.87 HDAC1 (0.48) HDAC2HDAC1HDAC3ACLYKDM4E
SCHEMBL2273011 0.86 HDAC1 (0.52) HDAC2HDAC1HDAC3ACLYKDM4E
SCHEMBL2271414 0.85 KMT2A (0.54) HDAC2HDAC1HDAC3MAPK1MEN1
SCHEMBL27989086 0.85 HDAC1 (0.56) HDAC2HDAC1HDAC3ACLYIGF2BP2
SCHEMBL2275605 0.85 ACLY (0.53) HDAC2HDAC1HDAC3ACLYKDM4E
SCHEMBL12117928 0.85 HDAC1 (0.48) HDAC2HDAC1ACLYDEGS1IGF2BP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 HDAC2 276/4885HDAC1 71/4885HDAC3 87/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.