SCHEMBL2275596

SCHEMBL2275596

CC(C)(C)OC(=O)c1ccc(Oc2ccccc2)cc1NC(=O)c1cccc(-c2ccccc2)c1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FABP1 P07148 5/20 0.51
MCL1 Q07820 2/20 0.49
BCL2L1 Q07817 1/20 0.49
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
ALDH1A1 P00352 1/20 0.48
GALK1 P51570 1/20 0.47
CASP6 P55212 1/20 0.47
PLEC Q15149 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
PYGM P11217 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
PGR P06401 1/20 0.46
POLB P06746 1/20 0.46
HDAC1 Q13547 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269847 0.90 HDAC2 (0.52) FABP1MCL1GALK1CASP6PLEC
SCHEMBL2273488 0.89 SUCNR1 (0.52) MEN1KMT2AALDH1A1HDAC1HDAC8
SCHEMBL2276375 0.88 GRIK1 (0.49) MEN1KMT2ATDP1PYGMNPC1
SCHEMBL12118089 0.88 ABL1 (0.44) FABP1MCL1GALK1CASP6PLEC
SCHEMBL2274026 0.86 PGR (0.61) MEN1KMT2APYGMNPC1RAB9A
SCHEMBL2275426 0.86 GRM5 (0.46) MEN1KMT2APYGMNPC1RAB9A
SCHEMBL2269139 0.86 CYP2C9 (0.47) MEN1KMT2AALDH1A1PYGMNPC1
SCHEMBL2275544 0.85 FABP1 (0.61) FABP1MCL1BCL2L1MEN1KMT2A
SCHEMBL2275425 0.85 NPC1 (0.43) MCL1MEN1KMT2ACASP6PYGM
SCHEMBL2269667 0.85 F10 (0.53) MEN1KMT2AALDH1A1PYGMPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 FABP1 4190/4885MCL1 1774/4885BCL2L1 1705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.