SCHEMBL2269667

SCHEMBL2269667

COc1ccc(C(=O)Nc2cc(Oc3ccccc3)ccc2C(=O)OC(C)(C)C)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 2/20 0.53
PGR P06401 1/20 0.53
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
PKM P14618 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
KDM4E B2RXH2 2/20 0.51
ALDH1A1 P00352 1/20 0.51
POLB P06746 1/20 0.51
HPGD P15428 1/20 0.51
NR1H4 Q96RI1 2/20 0.50
PPARG P37231 1/20 0.50
PPARD Q03181 1/20 0.50
GPBAR1 Q8TDU6 1/20 0.50
KCNK2 O95069 1/20 0.50
KCNK10 P57789 1/20 0.50
TP53 P04637 1/20 0.49
GAA P10253 1/20 0.49
SERPINE1 P05121 1/20 0.48
MAPT P10636 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274026 0.92 PGR (0.61) PGRMEN1KMT2AKDM4ENR1H4
SCHEMBL2269139 0.88 CYP2C9 (0.47) PGRMEN1KMT2AKDM4EALDH1A1
SCHEMBL1066620 0.86 MEN1 (0.66) F10MEN1KMT2APKMNPSR1
SCHEMBL2271007 0.86 MEN1 (0.69) F10PGRMEN1KMT2APKM
SCHEMBL2271662 0.86 KMT2A (0.57) MEN1KMT2ANPSR1KDM4EHPGD
SCHEMBL2269847 0.85 HDAC2 (0.52) PGRKDM4ENR1H4SERPINE1HDAC3
SCHEMBL2275596 0.85 FABP1 (0.51) PGRMEN1KMT2AALDH1A1POLB
SCHEMBL2276375 0.84 GRIK1 (0.49) PGRMEN1KMT2AMAPTHDAC1
SCHEMBL2277873 0.83 PYGM (0.44) PGRMEN1KMT2APKMKDM4E
SCHEMBL2270545 0.83 FFAR1 (0.56) MEN1KMT2AKDM4EPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 F10 62/4885PGR 3411/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.