SCHEMBL2270237

SCHEMBL2270237

O=C(Nc1cc(C=Cc2ccc(O)cc2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.57
PKM P14618 4/20 0.57
MEN1 O00255 4/20 0.57
MAPT P10636 4/20 0.57
TDP1 Q9NUW8 3/20 0.57
GRIK1 P39086 1/20 0.57
TTR P02766 1/20 0.55
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
PTPN1 P18031 2/20 0.51
SNCA P37840 4/20 0.50
LTC4S Q16873 1/20 0.50
DHODH Q02127 1/20 0.50
HNF4A P41235 1/20 0.49
KDM4D Q6B0I6 1/20 0.48
KDM4C Q9H3R0 1/20 0.48
ALDH1A1 P00352 2/20 0.47
KCNK2 O95069 1/20 0.47
KCNK10 P57789 1/20 0.47
SERPINE1 P05121 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270230 1.00 KMT2A (0.57) KMT2APKMMEN1MAPTTDP1
SCHEMBL2276651 0.93 PKM (0.62) KMT2APKMMEN1MAPTTDP1
SCHEMBL2276655 0.93 PKM (0.62) KMT2APKMMEN1MAPTTDP1
SCHEMBL2278460 0.90 MEN1 (0.56) KMT2APKMMEN1MAPTTDP1
SCHEMBL2278462 0.90 MEN1 (0.56) KMT2APKMMEN1MAPTTDP1
SCHEMBL2276918 0.88 SNCA (0.66) KMT2APKMMEN1MAPTTDP1
SCHEMBL2276923 0.88 SNCA (0.66) KMT2APKMMEN1MAPTTDP1
SCHEMBL2272933 0.87 KMT2A (0.55) KMT2APKMMEN1MAPTTDP1
SCHEMBL2272929 0.87 KMT2A (0.55) KMT2APKMMEN1MAPTTDP1
SCHEMBL2270271 0.86 PKM (0.54) KMT2APKMMEN1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KMT2A 1669/4885PKM 2367/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.