SCHEMBL2270271

SCHEMBL2270271

O=C(Nc1cc(/C=C/c2ccccc2O)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PKM P14618 3/20 0.54
KMT2A Q03164 3/20 0.54
MEN1 O00255 2/20 0.54
MAPT P10636 1/20 0.54
GRIK1 P39086 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
SNCA P37840 5/20 0.53
PTPN1 P18031 2/20 0.48
APP P05067 5/20 0.47
HNF4A P41235 1/20 0.46
TRPA1 O75762 1/20 0.45
LCK P06239 1/20 0.45
KDM4D Q6B0I6 1/20 0.45
KDM4C Q9H3R0 1/20 0.45
LTC4S Q16873 1/20 0.44
DHODH Q02127 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270275 1.00 PKM (0.54) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2276655 0.87 PKM (0.62) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2276651 0.87 PKM (0.62) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2271439 0.86 MEN1 (0.52) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2271435 0.86 MEN1 (0.52) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2270230 0.86 KMT2A (0.57) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2270237 0.86 KMT2A (0.57) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2268347 0.84 SNCA (0.48) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2268352 0.84 SNCA (0.48) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2278462 0.84 MEN1 (0.56) PKMKMT2AMEN1MAPTGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PKM 2367/4885KMT2A 1669/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.