SCHEMBL2268352

SCHEMBL2268352

CC(C)(C)OC(=O)c1ccc(C=Cc2ccccc2O)cc1NC(=O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SNCA P37840 9/20 0.48
APP P05067 2/20 0.42
KDM4E B2RXH2 2/20 0.41
MAPK1 P28482 2/20 0.41
PTPN1 P18031 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MAPT P10636 2/20 0.40
MEN1 O00255 1/20 0.40
PKM P14618 1/20 0.40
GRIK1 P39086 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
KCNMA1 Q12791 1/20 0.39
HDAC1 Q13547 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TRPA1 O75762 1/20 0.38
ABL1 P00519 1/20 0.38
ABCB1 P08183 1/20 0.38
BCR P11274 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2268347 1.00 SNCA (0.48) SNCAAPPKDM4EMAPK1PTPN1
SCHEMBL27696828 0.90 SNCA (0.47) SNCAAPPKDM4EMAPK1PTPN1
SCHEMBL2270355 0.88 SNCA (0.46) SNCAAPPKDM4EMAPK1PTPN1
SCHEMBL2270348 0.88 SNCA (0.46) SNCAAPPKDM4EMAPK1PTPN1
SCHEMBL2270275 0.84 PKM (0.54) SNCAAPPPTPN1MAPTMEN1
SCHEMBL2270271 0.84 PKM (0.54) SNCAAPPPTPN1MAPTMEN1
SCHEMBL2275290 0.83 SNCA (0.45) SNCAKDM4EMAPK1HSD17B10MAPT
SCHEMBL2275293 0.83 SNCA (0.45) SNCAKDM4EMAPK1HSD17B10MAPT
SCHEMBL2274101 0.82 SNCA (0.47) SNCAAPPKDM4EMAPK1HSD17B10
SCHEMBL2274106 0.82 SNCA (0.47) SNCAAPPKDM4EMAPK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SNCA 4741/4885APP 3574/4885KDM4E 1257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.