SCHEMBL2270348

SCHEMBL2270348

CC(C)(C)OC(=O)c1ccc(/C=C/c2ccc(O)cc2)cc1NC(=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 6/20 0.46
PKM P14618 3/20 0.46
MAPT P10636 2/20 0.46
RAB9A P51151 2/20 0.46
NPC1 O15118 1/20 0.46
APP P05067 2/20 0.44
PTPN1 P18031 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TTR P02766 1/20 0.43
ELANE P08246 2/20 0.42
PRTN3 P24158 2/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
GRIK1 P39086 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ALDH1A1 P00352 1/20 0.41
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270355 1.00 SNCA (0.46) SNCAPKMMAPTRAB9ANPC1
SCHEMBL27716684 0.89 MAPT (0.47) SNCAPKMMAPTRAB9ANPC1
SCHEMBL2268352 0.88 SNCA (0.48) SNCAPKMMAPTAPPPTPN1
SCHEMBL2268347 0.88 SNCA (0.48) SNCAPKMMAPTAPPPTPN1
SCHEMBL2274101 0.87 SNCA (0.47) SNCARAB9ANPC1APPKDM4E
SCHEMBL2274106 0.87 SNCA (0.47) SNCARAB9ANPC1APPKDM4E
SCHEMBL2276677 0.86 SNCA (0.59) SNCAMAPTRAB9ANPC1APP
SCHEMBL2276669 0.86 SNCA (0.59) SNCAMAPTRAB9ANPC1APP
SCHEMBL2275290 0.86 SNCA (0.45) SNCAPKMMAPTRAB9ANPC1
SCHEMBL2275293 0.86 SNCA (0.45) SNCAPKMMAPTRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SNCA 4741/4885PKM 2367/4885MAPT 4824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.