SCHEMBL2274101

SCHEMBL2274101

CC(C)(C)OC(=O)c1ccc(/C=C/c2ccc(OC(F)(F)F)cc2)cc1NC(=O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SNCA P37840 6/20 0.47
IGF2BP2 Q9Y6M1 1/20 0.47
KCNK2 O95069 2/20 0.44
KCNK10 P57789 2/20 0.44
TRPV1 Q8NER1 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
APP P05067 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPK1 P28482 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MTOR P42345 1/20 0.41
MEN1 O00255 1/20 0.40
MITF O75030 1/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 1/20 0.40
ELANE P08246 1/20 0.40
PRTN3 P24158 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274106 1.00 SNCA (0.47) SNCAIGF2BP2KCNK2KCNK10TRPV1
SCHEMBL27848573 0.90 IGF2BP2 (0.46) SNCAIGF2BP2KCNK2KCNK10TRPV1
SCHEMBL2272483 0.88 IGF2BP2 (0.57) SNCAIGF2BP2KCNK2KCNK10TRPV1
SCHEMBL2272471 0.88 IGF2BP2 (0.57) SNCAIGF2BP2KCNK2KCNK10TRPV1
SCHEMBL2270355 0.87 SNCA (0.46) SNCANPC1RAB9AAPPKDM4E
SCHEMBL2270348 0.87 SNCA (0.46) SNCANPC1RAB9AAPPKDM4E
SCHEMBL2276669 0.83 SNCA (0.59) SNCANPC1RAB9AAPPKDM4E
SCHEMBL2276677 0.83 SNCA (0.59) SNCANPC1RAB9AAPPKDM4E
SCHEMBL2275290 0.82 SNCA (0.45) SNCANPC1RAB9AKDM4EMAPK1
SCHEMBL2275293 0.82 SNCA (0.45) SNCANPC1RAB9AKDM4EMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SNCA 4741/4885IGF2BP2 4173/4885KCNK2 3527/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.