SCHEMBL2275293

SCHEMBL2275293

CC(C)(C)OC(=O)c1ccc(C=Cc2cccc(Cl)c2)cc1NC(=O)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 3/20 0.45
PPARG P37231 1/20 0.45
NR1H4 Q96RI1 1/20 0.45
RAB9A P51151 2/20 0.44
MAPT P10636 2/20 0.44
PKM P14618 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
ALDH1A1 P00352 2/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
MAOB P27338 1/20 0.44
NPC1 O15118 1/20 0.43
KCNA3 P22001 1/20 0.42
KCNK3 O14649 1/20 0.42
KCNK9 Q9NPC2 1/20 0.42
KCNMA1 Q12791 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
GRIK1 P39086 1/20 0.42
PYGL P06737 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275290 1.00 SNCA (0.45) SNCAPPARGNR1H4RAB9AMAPT
SCHEMBL27848563 0.90 SNCA (0.43) SNCAPPARGNR1H4RAB9AMAPT
SCHEMBL2270348 0.86 SNCA (0.46) SNCARAB9AMAPTPKMALDH1A1
SCHEMBL2270355 0.86 SNCA (0.46) SNCARAB9AMAPTPKMALDH1A1
SCHEMBL2276466 0.84 GRIK1 (0.57) SNCARAB9AMAPTPKMNPSR1
SCHEMBL2276459 0.84 GRIK1 (0.57) SNCARAB9AMAPTPKMNPSR1
SCHEMBL2275605 0.84 ACLY (0.53) PPARGNR1H4RAB9AMAPTNPSR1
SCHEMBL2268352 0.83 SNCA (0.48) SNCAMAPTPKMALDH1A1KCNMA1
SCHEMBL2268347 0.83 SNCA (0.48) SNCAMAPTPKMALDH1A1KCNMA1
SCHEMBL2274106 0.82 SNCA (0.47) SNCARAB9ANPC1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SNCA 4741/4885PPARG 2066/4885NR1H4 2482/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.