Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 3/20 | 0.31 |
| ▸ | CDK8 | P49336 | 3/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22705461 | 0.79 | LMNA (0.38) | LMNAHSD17B10ALDH1A1 | |
| SCHEMBL22705489 | 0.78 | LMNA (0.47) | LMNAHSD17B10ALDH1A1SMN1; SMN2HCRTR1 | |
| SCHEMBL22705441 | 0.76 | LMNA (0.35) | LMNAHSD17B10ALDH1A1 | |
| SCHEMBL22705468 | 0.76 | LMNA (0.40) | LMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22705465 | 0.75 | LMNA (0.34) | LMNAALDH1A1 | |
| SCHEMBL22705470 | 0.75 | LMNA (0.33) | LMNAHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL22705487 | 0.73 | RIPK1 (0.47) | — | |
| SCHEMBL24597803 | 0.65 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL22705449 | 0.64 | ENPP2 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL24597797 | 0.64 | L3MBTL1 (0.38) | ALDH1A1POLBSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020233618-A1 | INHIBITORS FOR PROGRAMMED CELL NECROSIS AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海有机化学研究所 (CN) | 2020-11-26 | — | — | WO | disclosed |