Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22705468 | 0.87 | LMNA (0.40) | TSHR | |
| SCHEMBL22705461 | 0.82 | LMNA (0.38) | TSHR | |
| SCHEMBL22705630 | 0.79 | OPRM1 (0.43) | OPRK1OPRM1 | |
| SCHEMBL22705474 | 0.78 | RIPK1 (0.67) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22705632 | 0.76 | DRD3 (0.38) | TSHR | |
| SCHEMBL24597803 | 0.75 | ALDH1A1 (0.43) | TSHR | |
| SCHEMBL22705470 | 0.73 | LMNA (0.33) | TSHROPRK1OPRM1 | |
| SCHEMBL22705486 | 0.73 | LMNA (0.35) | — | |
| SCHEMBL24597797 | 0.73 | L3MBTL1 (0.38) | OPRK1OPRM1OPRD1 | |
| SCHEMBL22705441 | 0.73 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020233618-A1 | INHIBITORS FOR PROGRAMMED CELL NECROSIS AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海有机化学研究所 (CN) | 2020-11-26 | — | — | WO | disclosed |