SCHEMBL2271189

SCHEMBL2271189

CC(C)(C)OC(=O)Oc1ccc(-c2ccc(C(=O)OC(C)(C)C)c(NC(=O)c3ccc(F)cc3)c2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 4/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
TSHR P16473 1/20 0.45
CYP2C19 P33261 1/20 0.45
HDAC2 Q92769 3/20 0.43
PRTN3 P24158 3/20 0.43
KDM4E B2RXH2 4/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
GAA P10253 1/20 0.41
IGF2BP2 Q9Y6M1 1/20 0.41
HDAC1 Q13547 2/20 0.41
PTPN1 P18031 1/20 0.40
KMT2A Q03164 1/20 0.40
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12395478 0.92 KCNK2 (0.47) ELANEHDAC2SMN1; SMN2NPC1RAB9A
SCHEMBL2272448 0.81 CYP1A2 (0.47) CYP1A2CYP2D6TSHRCYP2C19HDAC2
SCHEMBL2270803 0.81 CYP1A2 (0.46) CYP1A2CYP2D6TSHRCYP2C19HDAC2
SCHEMBL2276199 0.80 ALDH1A1 (0.51) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL2272065 0.80 ALDH1A1 (0.40) ELANETSHRPRTN3KDM4ELMNA
SCHEMBL2269847 0.78 HDAC2 (0.52) HDAC2KDM4EIGF2BP2HDAC1
SCHEMBL2274754 0.76 HDAC2 (0.53) ELANEHDAC2PRTN3KDM4EIGF2BP2
SCHEMBL2276764 0.75 HDAC2 (0.54) CYP1A2CYP2D6TSHRCYP2C19HDAC2
SCHEMBL1317449 0.75 HDAC2 (0.41) TSHRHDAC2HDAC1KMT2AALDH1A1
SCHEMBL2273488 0.74 SUCNR1 (0.52) HDAC2HDAC1KMT2AALDH1A1SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ELANE 427/4885CYP1A2 883/4885CYP2D6 556/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.