SCHEMBL22719923

SCHEMBL22719923

COc1ccc2c(ccn2Cc2cnc(C(=O)NC3CC3)c3c2COC(C)(C)O3)c1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 4/20 0.40
MTNR1B P49286 4/20 0.40
HPGDS O60760 8/20 0.38
HDAC8 Q9BY41 2/20 0.37
HDAC6 Q9UBN7 2/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC3 O15379 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MCHR1 Q99705 1/20 0.36
CNR1 P21554 1/20 0.36
CNR2 P34972 1/20 0.36
SMYD3 Q9H7B4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22719921 0.91 NPY5R (0.39) HPGDSMCHR1
SCHEMBL22738309 0.90 EGLN1 (0.44) MTNR1AMTNR1BHDAC8HDAC6HDAC11
SCHEMBL22738287 0.88 MTNR1A (0.41) MTNR1AMTNR1BHDAC8HDAC6HDAC11
SCHEMBL22738237 0.85 PDE4B (0.36) HDAC6HDAC1ALDH1A1
SCHEMBL22738238 0.81 ALDH1A1 (0.37) HDAC8HDAC6HDAC11HDAC3HDAC1
SCHEMBL22719901 0.81 EGLN1 (0.35) HDAC8HDAC6HDAC11HDAC3HDAC1
SCHEMBL22719930 0.80 PPARG (0.39)
SCHEMBL22738235 0.80 ALDH1A1 (0.37) HDAC8HDAC6HDAC11HDAC3HDAC1
SCHEMBL22738232 0.80 ALDH1A1 (0.35) MTNR1AMTNR1BHDAC8HDAC6HDAC11
SCHEMBL22719960 0.79 PPARG (0.38) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020237374-A1 PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL MONTREAL HEART INSTITUTE (CA) 2020-12-03 WO disclosed
WO-2020237374-A1 PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL MONTREAL HEART INSTITUTE (CA) 2020-12-03 WO disclosed