SCHEMBL2272304

SCHEMBL2272304

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1ccc(N2CCOCC2)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.55
KMT2A Q03164 1/20 0.55
NTRK1 P04629 1/20 0.52
DGAT1 O75907 2/20 0.51
SMN1; SMN2 Q16637 3/20 0.48
KDM4E B2RXH2 1/20 0.48
CSF1R P07333 1/20 0.48
DAPK1 P53355 1/20 0.48
KCNH2 Q12809 1/20 0.48
MAPK13 O15264 1/20 0.48
KCNQ3 O43525 1/20 0.48
KCNQ2 O43526 1/20 0.48
MAPT P10636 3/20 0.48
CYP1A2 P05177 2/20 0.48
CYP2C19 P33261 1/20 0.48
LMNA P02545 1/20 0.48
HTT P42858 1/20 0.48
ALDH1A1 P00352 2/20 0.47
STAT3 P40763 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276392 0.90 DGAT1 (0.50) DGAT1CSF1RDAPK1KCNH2
SCHEMBL2272389 0.87 NTRK1 (0.64) NPC1KMT2ANTRK1
SCHEMBL2274325 0.86 HDAC2 (0.61) DGAT1SMN1; SMN2KDM4EKCNH2KCNQ3
SCHEMBL2270356 0.84 SERPINE1 (0.48) DGAT1KDM4ECYP1A2CYP2C19
SCHEMBL2270290 0.84 AOC3 (0.48) NPC1SMN1; SMN2KDM4EKCNQ3KCNQ2
SCHEMBL2275080 0.79 HDAC1 (0.46) NPC1KMT2ADGAT1CSF1RDAPK1
SCHEMBL1330528 0.78 NPC1 (0.62) NPC1KMT2ADGAT1SMN1; SMN2KDM4E
SCHEMBL14096286 0.77 DGAT1 (0.59) NPC1KMT2ADGAT1SMN1; SMN2KCNQ3
SCHEMBL5224545 0.76 HDAC1 (0.70) SMN1; SMN2KDM4EKCNH2
SCHEMBL2271588 0.76 SERPINE1 (0.64) NPC1KMT2AMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 NPC1 4836/4885KMT2A 1669/4885NTRK1 4364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.