Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728334 | 0.83 | RIPK1 (0.41) | IDO1SLC6A2SLC6A4 | |
| SCHEMBL22728321 | 0.80 | IDO1 (0.42) | IDO1SLC6A2SLC6A4 | |
| SCHEMBL22728326 | 0.76 | IDO1 (0.45) | IDO1SLC6A2SLC6A4SLC6A3PPARG | |
| SCHEMBL22728324 | 0.76 | AKR1B1 (0.35) | IDO1P2RX7EPHX2 | |
| SCHEMBL22728386 | 0.75 | OPRL1 (0.36) | SLC6A2SLC6A4 | |
| SCHEMBL9969387 | 0.75 | IDO1 (0.56) | IDO1SLC6A2SLC6A4P2RX7SLC6A3 | |
| SCHEMBL8417818 | 0.75 | IDO1 (0.59) | IDO1SLC6A2SLC6A4P2RX7SLC6A3 | |
| SCHEMBL958307 | 0.74 | IDO1 (0.54) | IDO1SLC6A2SLC6A4P2RX7SLC6A3 | |
| SCHEMBL22728383 | 0.73 | CTSS (0.42) | P2RX7 | |
| SCHEMBL22728332 | 0.73 | IDO1 (0.45) | IDO1SLC6A4P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |