Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728407 | 0.95 | OPRM1 (0.42) | SIGMAR1EBPL3MBTL1MAOAOPRM1 | |
| SCHEMBL22728397 | 0.89 | OPRM1 (0.44) | SIGMAR1EBPMAOAOPRM1DRD3 | |
| SCHEMBL14450992 | 0.77 | SIGMAR1 (0.46) | SIGMAR1EBPL3MBTL1MAOA | |
| SCHEMBL4397841 | 0.76 | GRM2 (0.43) | SIGMAR1EBPADRA1ASLC6A3MEN1 | |
| SCHEMBL2440582 | 0.73 | OPRM1 (0.42) | SIGMAR1EBPL3MBTL1MAOAOPRM1 | |
| SCHEMBL2436941 | 0.72 | DRD2 (0.45) | SIGMAR1EBPMAOAOPRM1DRD3 | |
| SCHEMBL4557580 | 0.71 | FDPS (0.46) | SIGMAR1L3MBTL1MAOAOPRM1DRD3 | |
| SCHEMBL4742953 | 0.71 | MAOA (0.52) | SIGMAR1L3MBTL1MAOAMAOBMEN1 | |
| Water SCHEMBL27368925 | 0.71 | KCNH2 (0.66) | SIGMAR1L3MBTL1MAOAOPRM1DRD3 | |
| Acetonitrile SCHEMBL28809015 | 0.71 | KCNH2 (0.61) | SIGMAR1KCNH2CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |