SCHEMBL227295

SCHEMBL227295

COc1cccc([C@H]2O[C@H](CC(=O)N3CCC(CC(=O)O)CC3)C(=O)N(CC(C)(C)CO)c3ccc(Cl)cc32)c1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FDFT1 P37268 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30649033 1.00 FDFT1 (1.00) FDFT1
SCHEMBL14887010 1.00 FDFT1 (1.00) FDFT1
SCHEMBL4682693 0.95 FDFT1 (0.91) FDFT1
SCHEMBL16116566 0.94 FDFT1 (0.90) FDFT1
SCHEMBL4105356 0.94 FDFT1 (0.90) FDFT1
Lapaquistat Acetate SCHEMBL206424 0.93 FDFT1 (1.00) FDFT1
Lapaquistat Acetate SCHEMBL8007641 0.93 FDFT1 (1.00) FDFT1
Lapaquistat Acetate SCHEMBL29395209 0.93 FDFT1 (1.00) FDFT1
Lapaquistat Acetate SCHEMBL12882274 0.93 FDFT1 (1.00) FDFT1
Lapaquistat Acetate SCHEMBL29379346 0.93 FDFT1 (1.00) FDFT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 360 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124215-A1 METHODS OF TREATMENT OF INTESTINAL INFECTIONS THE FRANCIS CRICK INST LIMITED (GB) 2026-05-07 US claimed
EP-4659812-A1 DETECTION METHODS AND COMBINATION THERAPIES OF CELLS WITH EXTRACELLULAR RAS EXPRESSION Bumm, Thomas (DE) 2025-12-10 EP claimed
EP-4598518-A1 METHODS OF TREATMENT OF INTESTINAL INFECTIONS The Francis Crick Institute Limited (GB) 2025-08-13 EP claimed
WO-2024074554-A1 METHODS OF TREATMENT OF INTESTINAL INFECTIONS THE FRANCIS CRICK INSTITUTE LIMITED (GB) 2024-04-11 WO claimed
CN-116744934-A Inhaled statins for the treatment of viral respiratory diseases 加利福尼亚大学董事会 2023-09-12 CN claimed
US-20230172849-A1 INHALED STATINS FOR TREATMENT OF VIRAL RESPIRATORY DISEASES UNIV CALIFORNIA (US) 2023-06-08 US claimed
EP-4146340-A1 INHALED STATINS FOR TREATMENT OF VIRAL RESPIRATORY DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-03-15 EP claimed
WO-2021226479-A1 INHALED STATINS FOR TREATMENT OF VIRAL RESPIRATORY DISEASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-11-11 WO claimed
US-11136342-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2021-10-05 US claimed
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME ACORDA THERAPEUTICS, INC. 2020-05-21 US claimed
US-20090118255-A1 Crp Lowering Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-05-07 US claimed
US-20080132483-A1 Agent for preventing or treating organ functional disorders and organ dysfunction TAKEDA PHARMACEUTICAL COMPANY LIMITED 2008-06-05 US claimed
US-20080113965-A1 Compound having inhibitory activity against squalene synthase or a salt or prodrug thereof, for example, N-[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetic acid; myalgia or rhabdomyolysis treatment TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-05-15 US claimed
US-20060241096-A1 Agent for preventing or treating organ functional disorders and organ dysfunction SUGIYAMA YASUO 2006-10-26 US claimed
US-20060052362-A1 Skeletal muscle protecting agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-03-09 US claimed
EP-1600166-A1 SKELETAL MUSCLE PROTECTING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-11-30 EP claimed
US-20040204500-A1 Preventives/remedies for organ functional disorders and organ dysfunction TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-10-14 US claimed
EP-1407782-A1 PREVENTIVES/REMEDIES FOR ORGAN FUNCTIONAL DISORDERS AND ORGAN DYSFUNCTION Takeda Chemical Industries, Ltd. (JP) 2004-04-14 EP claimed
EP-0862562-B1 BENZOXAZEPINE COMPOUNDS, THEIR PRODUCTION AND USE AS LIPID LOWERING AGENTS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-07-04 EP claimed
US-6110909-A SQUALENE SYNTHETASE INHIBITING ANTILIPEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-08-29 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124215-A1 METHODS OF TREATMENT OF INTESTINAL INFECTIONS FDFT1, FNTA, FNTB FDFT1 1/4885
US-20080132483-A1 Agent for preventing or treating organ functional disorders and organ dysfunction FDFT1, SQOR, DHPS FDFT1 1/4885
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME CA6, CA7, CA4 FDFT1 4716/4885
US-20040204500-A1 Preventives/remedies for organ functional disorders and organ dysfunction FDFT1, SQOR, DHPS FDFT1 1/4885
US-11136342-B2 Carbonate prodrugs and methods of using the same CA6, CA7, CA4 FDFT1 4716/4885
US-20090118255-A1 Crp Lowering Agent SPR, RBP1, HMGCR FDFT1 7/4885
US-20080113965-A1 Compound having inhibitory activity against squalene synthase or a salt or prodrug thereof, for example, N-[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetic acid; myalgia or rhabdomyolysis treatment SQLE, DHPS, COASY FDFT1 13/4885
US-20060052362-A1 Skeletal muscle protecting agent GYS1, CPT1B, TNNC1 FDFT1 8/4885
US-20060241096-A1 Agent for preventing or treating organ functional disorders and organ dysfunction FDFT1, SQOR, DHPS FDFT1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.