Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530337 | 0.82 | MET (0.42) | METPDE10A | |
| SCHEMBL22729927 | 0.79 | MET (0.34) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL20530307 | 0.78 | MET (0.38) | MET | |
| SCHEMBL22729930 | 0.77 | MET (0.36) | MET | |
| SCHEMBL20530344 | 0.75 | GPR119 (0.38) | MET | |
| SCHEMBL20530300 | 0.73 | MET (0.40) | MET | |
| SCHEMBL22729920 | 0.73 | MET (0.36) | METCYP2C9 | |
| SCHEMBL20530338 | 0.71 | MET (0.42) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL20530289 | 0.71 | MET (0.43) | MET | |
| SCHEMBL20530302 | 0.70 | MET (0.51) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831073-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES | RHIZEN PHARMACEUTICALS S A (CH) | 2020-12-09 | — | — | EP | claimed |