SCHEMBL2273286

SCHEMBL2273286

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)OC(=O)C(F)(F)F)c1cccnc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB1 P08183 1/20 0.49
▸ TP53 P04637 1/20 0.48
▸ RAB9A P51151 3/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ NPC1 O15118 2/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ KDM4E B2RXH2 2/20 0.46
▸ HDAC1 Q13547 5/20 0.46
▸ EPHX2 P34913 1/20 0.45
▸ RXFP1 Q9HBX9 1/20 0.44
▸ LMNA P02545 2/20 0.43
▸ MAPT P10636 2/20 0.43
▸ USP2 O75604 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ ABCG2 Q9UNQ0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL2273285 0.86 HDAC1 (0.51) ABCB1TP53RAB9ASMN1; SMN2NPC1
SCHEMBL2273873 0.81 ABCB1 (0.60) ABCB1RAB9ANPC1HDAC1EPHX2
SCHEMBL4218736 0.77 TRPV1 (0.48) SMN1; SMN2NPC1KDM4EMAPTALDH1A1
SCHEMBL4218343 0.75 HDAC6 (0.38) SMN1; SMN2NPC1KDM4EMAPTALDH1A1
SCHEMBL4220427 0.74 TRPV1 (0.42) RAB9ASMN1; SMN2NPC1MEN1KMT2A
SCHEMBL2275929 0.71 KMT2A (0.62) MEN1KMT2AHDAC1MAPT
SCHEMBL2277701 0.71 IGF2BP2 (0.57) RAB9ASMN1; SMN2NPC1MEN1KMT2A
SCHEMBL4718567 0.71 ALDH1A1 (0.57) KMT2AKDM4EHDAC1LMNAMAPT
SCHEMBL2270705 0.71 ACLY (0.59) MEN1KMT2ARXFP1MAPT
SCHEMBL2274939 0.70 PLK1 (0.55) RAB9ANPC1MEN1KMT2ARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 — — US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 — — US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ABCB1 2740/4885TP53 858/4885RAB9A 2238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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