Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.33 |
| ▸ | TAB1 | Q15750 | 5/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735887 | 0.87 | ALDH1A1 (0.34) | ATRMAP3K7TAB1ROCK2ROCK1 | |
| SCHEMBL22736207 | 0.81 | JAK1 (0.37) | JAK1ROCK2ROCK1JAK2TYK2 | |
| SCHEMBL22735884 | 0.80 | BTK (0.42) | JAK1ROCK2ROCK1JAK2TYK2 | |
| SCHEMBL29480529 | 0.80 | BTK (0.42) | JAK1ROCK2ROCK1JAK2TYK2 | |
| SCHEMBL22735888 | 0.78 | LRRK2 (0.34) | JAK1ROCK2ROCK1JAK2TYK2 | |
| SCHEMBL22735724 | 0.74 | JAK1 (0.36) | JAK1JAK2 | |
| SCHEMBL22736139 | 0.74 | BTK (0.41) | JAK1ROCK2ROCK1JAK2 | |
| SCHEMBL22736529 | 0.73 | PIK3CD (0.36) | JAK1JAK2PIK3CDRET | |
| SCHEMBL29480545 | 0.71 | BTK (0.39) | JAK1ROCK2JAK2 | |
| SCHEMBL22735893 | 0.69 | JAK1 (0.33) | JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |