Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735735 | 0.78 | ATR (0.34) | ROCK2ROCK1JAK2JAK1TYK2 | |
| SCHEMBL22736207 | 0.77 | JAK1 (0.37) | ROCK2ROCK1JAK2JAK1TYK2 | |
| SCHEMBL22735884 | 0.76 | BTK (0.42) | ROCK2ROCK1JAK2JAK1TYK2 | |
| SCHEMBL29480529 | 0.76 | BTK (0.42) | ROCK2ROCK1JAK2JAK1TYK2 | |
| SCHEMBL22735887 | 0.74 | ALDH1A1 (0.34) | ROCK2ROCK1 | |
| SCHEMBL22735724 | 0.71 | JAK1 (0.36) | JAK2JAK1 | |
| SCHEMBL22735893 | 0.71 | JAK1 (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22736139 | 0.70 | BTK (0.41) | ROCK2ROCK1JAK2JAK1 | |
| SCHEMBL29480545 | 0.68 | BTK (0.39) | ROCK2JAK2JAK1JAK3 | |
| SCHEMBL29480508 | 0.66 | BTK (0.41) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |