Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735888 | 0.71 | LRRK2 (0.34) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL22735735 | 0.69 | ATR (0.34) | JAK1JAK2TYK2 | |
| SCHEMBL22736207 | 0.68 | JAK1 (0.37) | JAK1JAK3JAK2TYK2CCNT1 | |
| SCHEMBL22735884 | 0.67 | BTK (0.42) | JAK1JAK3JAK2TYK2CCNT1 | |
| SCHEMBL22735724 | 0.65 | JAK1 (0.36) | JAK1JAK2 | |
| SCHEMBL22735887 | 0.65 | ALDH1A1 (0.34) | — | |
| SCHEMBL22736139 | 0.65 | BTK (0.41) | JAK1JAK2 | |
| SCHEMBL26789531 | 0.64 | ALDH1A1 (0.51) | — | |
| SCHEMBL22716862 | 0.63 | JAK2 (0.41) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26789772 | 0.59 | SMN1; SMN2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |