N,N-Dimethyltryptamine

N,N-Dimethyltryptamine

SCHEMBL22736733

[2H]C([2H])(Cc1c[nH]c2ccccc12)N(C)C

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 7/20 0.77
HTR1A P08908 5/20 0.77
HTR2C P28335 4/20 0.77
HTR6 P50406 4/20 0.77
HTR2B P41595 3/20 0.77
HTR1B P28222 3/20 0.77
HTR7 P34969 3/20 0.77
ADRA2A P08913 2/20 0.77
ADRA2B P18089 2/20 0.77
ADRA2C P18825 2/20 0.77
MAOA P21397 2/20 0.77
ADRA1D P25100 2/20 0.77
CHRNB4 P30926 2/20 0.77
CHRNA3 P32297 2/20 0.77
ADRA1A P35348 2/20 0.77
HRH1 P35367 2/20 0.77
ADRA1B P35368 2/20 0.77
HTR5A P47898 2/20 0.77
SLC6A4 P31645 1/20 0.67
CYP3A4 P08684 3/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N,N-Dimethyltryptamine SCHEMBL25174555 0.90 HTR2A (0.65) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL25180279 0.88 HTR1A (1.00) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL22736735 0.87 MEN1 (0.65) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL22736730 0.87 HTR2A (0.71) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL22772906 0.87 MEN1 (0.65) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL27221709 0.83 HTR2A (1.00) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL335710 0.83 HTR2A (1.00) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL29350959 0.83 HTR2A (1.00) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL23069121 0.81 HTR2A (0.97) HTR2AHTR1AHTR2CHTR6HTR2B
N,N-Dimethyltryptamine SCHEMBL25285129 0.81 HTR2A (0.97) HTR2AHTR1AHTR2CHTR6HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12042564-B2 Therapeutic solid dosage forms CYBIN UK LTD (GB) 2024-07-23 US claimed
US-11771681-B2 Therapeutic compounds SMALL PHARMA LTD (GB) 2023-10-03 US claimed
US-20230149293-A1 INJECTABLE AND INHALABLE FORMULATIONS CYBIN UK LTD (GB) 2023-05-18 US claimed
EP-4149460-A1 THERAPEUTIC SOLID DOSAGE FORMS Small Pharma Ltd (GB) 2023-03-22 EP claimed
US-20220313660-A1 INJECTABLE FORMULATIONS SMALL PHARMA LTD (GB) 2022-10-06 US claimed
US-20220168275-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS SMALL PHARMA LTD (GB) 2022-06-02 US claimed
EP-3826632-B1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS SMALL PHARMA LTD (GB) 2022-05-18 EP claimed
CN-114096246-A Therapeutic compositions comprising deuterated or partially deuterated N, N-dimethyltryptamine compounds 斯玛尔药物有限公司 2022-02-25 CN claimed
US-20210378969-A1 THERAPEUTIC SOLID DOSAGE FORMS SMALL PHARMA LTD. (GB) 2021-12-09 US claimed
EP-3902541-A2 DEUTERATED COMPOUNDS Small Pharma Ltd (GB) 2021-11-03 EP claimed
WO-2021116503-A2 DEUTERATED COMPOUNDS SMALL PHARMA LTD (GB) 2021-06-17 WO claimed
US-20200390746-A1 Therapeutic Compounds SMALL PHARMA LTD (GB) 2020-12-17 US claimed
EP-4704806-A1 INJECTABLE PHARMACEUTICAL FORMULATIONS Cybin IRL Limited (IE) 2026-03-11 EP disclosed
EP-4654967-A1 TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS BY PARENTERAL ADMINISTRATION OF A SINGLE, EFFECTIVE PARENTERAL DOSE OF A SHORT-ACTING PSYCHEDELIC AGENT Cybin UK Ltd (GB) 2025-12-03 EP disclosed
US-20250360148-A1 SOLID DISPERSIONS OF PSILOCYBIN CYBIN IRL LIMITED (IE) 2025-11-27 US disclosed
US-20250262145-A1 INJECTABLE AND INHALABLE FORMULATIONS CYBIN UK LTD (GB) 2025-08-21 US disclosed
EP-3826632-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS Small Pharma Ltd (GB) 2021-06-02 EP disclosed
US-20200390746-A1 Therapeutic Compounds SMALL PHARMA LTD (GB) 2020-12-17 US disclosed
US-20200390746-A1 Therapeutic Compounds SMALL PHARMA LTD (GB) 2020-12-17 US disclosed
WO-2020245133-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS SMALL PHARMA LTD (GB) 2020-12-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12042564-B2 Therapeutic solid dosage forms SLC6A4, HTR5A, SLC6A3 HTR2A 10/4885HTR1A 7/4885HTR2C 6/4885
US-20250262145-A1 INJECTABLE AND INHALABLE FORMULATIONS HTR5A, HTR1B, HTR2B HTR2A 21/4885HTR1A 7/4885HTR2C 5/4885
US-11771681-B2 Therapeutic compounds HTR5A, DRD4, DRD2 HTR2A 44/4885HTR1A 25/4885HTR2C 22/4885
US-20250360148-A1 SOLID DISPERSIONS OF PSILOCYBIN HTR2B, HTR2A, HTR2C HTR2A 2/4885HTR1A 11/4885HTR2C 3/4885
US-20220313660-A1 INJECTABLE FORMULATIONS SLC6A4, HTR5A, SLC6A3 HTR2A 15/4885HTR1A 17/4885HTR2C 9/4885
US-20200390746-A1 Therapeutic Compounds HTR5A, DRD4, DRD2 HTR2A 44/4885HTR1A 25/4885HTR2C 22/4885
US-20210378969-A1 THERAPEUTIC SOLID DOSAGE FORMS SLC6A4, HTR5A, SLC6A3 HTR2A 10/4885HTR1A 7/4885HTR2C 6/4885
US-20230149293-A1 INJECTABLE AND INHALABLE FORMULATIONS HTR5A, HTR1B, HTR2B HTR2A 21/4885HTR1A 7/4885HTR2C 5/4885
US-20220168275-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS DRD2, CHRND, HTR5A HTR2A 28/4885HTR1A 15/4885HTR2C 14/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.