N,N-Dimethyltryptamine

N,N-Dimethyltryptamine

SCHEMBL22736735

[2H]C([2H])(c1c[nH]c2ccccc12)C([2H])([2H])N(C)C

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.65
KMT2A Q03164 4/20 0.65
ALDH1A1 P00352 4/20 0.65
CYP3A4 P08684 3/20 0.65
KDM4E B2RXH2 3/20 0.65
HSD17B10 Q99714 2/20 0.65
CYP2D6 P10635 2/20 0.65
TSHR P16473 1/20 0.65
CYP2C19 P33261 1/20 0.65
HTR2A P28223 7/20 0.61
HTR1A P08908 6/20 0.61
HTR2C P28335 5/20 0.61
HTR2B P41595 4/20 0.61
HTR6 P50406 5/20 0.60
HTR1B P28222 4/20 0.60
HTR7 P34969 4/20 0.60
ADRA2A P08913 3/20 0.60
ADRA2B P18089 2/20 0.60
ADRA2C P18825 2/20 0.60
MAOA P21397 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N,N-Dimethyltryptamine SCHEMBL31322057 0.92 MEN1 (0.58) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL25204923 0.90 HTR2A (0.66) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL22772906 0.87 MEN1 (0.65) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL22772908 0.87 HTR1A (0.71) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL22736733 0.87 HTR2A (0.77) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL22736729 0.87 MEN1 (0.65) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL30483454 0.81 HTR2A (0.58) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL30448862 0.81 MEN1 (0.57) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL22736734 0.80 MEN1 (0.65) MEN1KMT2AALDH1A1CYP3A4KDM4E
N,N-Dimethyltryptamine SCHEMBL22736730 0.80 HTR2A (0.71) MEN1KMT2AALDH1A1CYP3A4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220313660-A1 INJECTABLE FORMULATIONS SMALL PHARMA LTD (GB) 2022-10-06 US claimed
US-20220168275-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS SMALL PHARMA LTD (GB) 2022-06-02 US claimed
US-20200390746-A1 Therapeutic Compounds SMALL PHARMA LTD (GB) 2020-12-17 US claimed
EP-4463440-A1 TRYPTAMINE COMPOSITIONS AND METHODS Cybin IRL Limited (IE) 2024-11-20 EP disclosed
US-20240342126-A1 HALLUCINOGEN-FATTY ACID COMBINATION MINDSET PHARMA INC. (CA) 2024-10-17 US disclosed
US-12042564-B2 Therapeutic solid dosage forms CYBIN UK LTD (GB) 2024-07-23 US disclosed
US-20240165079-A1 COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS CONSEJO SUPERIOR INVESTIGACION (ES) 2024-05-23 US disclosed
CN-116056763-B Therapeutic compositions comprising deuterated or partially deuterated N, N-dimethyltryptamine compounds 赛本英国有限公司 2024-03-05 CN disclosed
US-20240016782-A1 INHALABLE FORMULATIONS CYBIN UK LTD (GB) 2024-01-18 US disclosed
EP-4275753-A2 DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS Small Pharma Ltd (GB) 2023-11-15 EP disclosed
US-20230330063-A1 COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS CONSEJO SUPERIOR INVESTIGACION (ES) 2023-10-19 US disclosed
US-20210403426-A1 DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS SMALL PHARMA LTD (GB) 2021-12-30 US disclosed
US-20210378969-A1 THERAPEUTIC SOLID DOSAGE FORMS SMALL PHARMA LTD. (GB) 2021-12-09 US disclosed
EP-3902541-A2 DEUTERATED COMPOUNDS Small Pharma Ltd (GB) 2021-11-03 EP disclosed
WO-2021116503-A2 DEUTERATED COMPOUNDS SMALL PHARMA LTD (GB) 2021-06-17 WO disclosed
EP-3826632-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS Small Pharma Ltd (GB) 2021-06-02 EP disclosed
US-20200397752-A1 COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS Consejo Superior de Investigacions Cientificas (CSIS) (ES) 2020-12-24 US disclosed
US-20200390746-A1 Therapeutic Compounds SMALL PHARMA LTD (GB) 2020-12-17 US disclosed
US-20200390746-A1 Therapeutic Compounds SMALL PHARMA LTD (GB) 2020-12-17 US disclosed
WO-2020245133-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS SMALL PHARMA LTD (GB) 2020-12-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12042564-B2 Therapeutic solid dosage forms SLC6A4, HTR5A, SLC6A3 MEN1 442/4885KMT2A 625/4885ALDH1A1 2236/4885
US-20200397752-A1 COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS HTR2A, HTR2C, HTR1A MEN1 3080/4885KMT2A 344/4885ALDH1A1 1445/4885
US-20230330063-A1 COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS HTR2A, HTR2C, HTR1A MEN1 3137/4885KMT2A 305/4885ALDH1A1 1354/4885
US-20240342126-A1 HALLUCINOGEN-FATTY ACID COMBINATION FAAH, HTR5A, FAAH2 MEN1 1324/4885KMT2A 1032/4885ALDH1A1 1852/4885
US-20220313660-A1 INJECTABLE FORMULATIONS SLC6A4, HTR5A, SLC6A3 MEN1 125/4885KMT2A 1550/4885ALDH1A1 2999/4885
US-20210403426-A1 DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS TPH1, DRD4, TPH2 MEN1 751/4885KMT2A 1380/4885ALDH1A1 4587/4885
US-20240165079-A1 COMBINATION PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND/OR PSYCHIATRIC DISORDERS HTR2A, HTR2C, HTR1A MEN1 3080/4885KMT2A 344/4885ALDH1A1 1445/4885
US-20240016782-A1 INHALABLE FORMULATIONS HTR2B, TPH1, HTR1B MEN1 849/4885KMT2A 1523/4885ALDH1A1 3126/4885
US-20200390746-A1 Therapeutic Compounds HTR5A, DRD4, DRD2 MEN1 1286/4885KMT2A 2140/4885ALDH1A1 2084/4885
US-20210378969-A1 THERAPEUTIC SOLID DOSAGE FORMS SLC6A4, HTR5A, SLC6A3 MEN1 442/4885KMT2A 625/4885ALDH1A1 2236/4885
US-20220168275-A1 THERAPEUTIC COMPOSITIONS COMPRISING DEUTERATED OR PARTIALLY DEUTERATED N,N-DIMETHYLTRYPTAMINE COMPOUNDS DRD2, CHRND, HTR5A MEN1 1267/4885KMT2A 1778/4885ALDH1A1 2706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.