SCHEMBL2273979

SCHEMBL2273979

Cc1cccc(C(=O)Nc2cc(CCc3ccccc3)ccc2C(=O)O)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.58
MEN1 O00255 6/20 0.58
KMT2A Q03164 6/20 0.58
NPC1 O15118 2/20 0.57
RAB9A P51151 2/20 0.57
PLK1 P53350 5/20 0.57
PLK3 Q9H4B4 1/20 0.57
GFER P55789 1/20 0.55
POLB P06746 3/20 0.54
KDM4E B2RXH2 3/20 0.54
PKM P14618 2/20 0.53
FFAR1 O14842 1/20 0.52
TP53 P04637 1/20 0.52
GLA P06280 1/20 0.52
KCNK3 O14649 1/20 0.51
KCNK9 Q9NPC2 1/20 0.51
MAPT P10636 2/20 0.51
NPSR1 Q6W5P4 1/20 0.51
HCAR2 Q8TDS4 1/20 0.50
LMNA P02545 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274146 0.90 PLK1 (0.56) ALDH1A1MEN1KMT2APLK1PLK3
SCHEMBL2275929 0.88 KMT2A (0.62) MEN1KMT2APLK1PLK3PKM
SCHEMBL2267959 0.88 PLK1 (0.65) ALDH1A1MEN1KMT2ANPC1RAB9A
SCHEMBL2272111 0.86 SUCNR1 (0.59) MEN1KMT2APKMMAPTHCAR2
SCHEMBL2270906 0.85 MEN1 (0.56) ALDH1A1MEN1KMT2ARAB9APLK1
SCHEMBL2273138 0.85 GRIK1 (0.59) MEN1KMT2AKDM4EPKMKCNK3
SCHEMBL2275745 0.85 NPC1 (0.56) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL2273122 0.84 PLK1 (0.57) ALDH1A1MEN1KMT2ANPC1RAB9A
SCHEMBL2271236 0.83 PLK1 (0.60) MEN1KMT2ANPC1RAB9APLK1
SCHEMBL2272409 0.83 PLK1 (0.63) MEN1KMT2ANPC1RAB9APLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ALDH1A1 645/4885MEN1 3105/4885KMT2A 1669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.