SCHEMBL2270906

SCHEMBL2270906

Cc1ccc(C(=O)Nc2cc(CCc3ccccc3)ccc2C(=O)O)cc1C

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
TDP1 Q9NUW8 2/20 0.56
MAPT P10636 2/20 0.56
LMNA P02545 1/20 0.56
RAB9A P51151 1/20 0.56
PLK1 P53350 6/20 0.54
PLK3 Q9H4B4 4/20 0.54
ALDH1A1 P00352 2/20 0.53
KDM4E B2RXH2 1/20 0.53
NR1H4 Q96RI1 1/20 0.49
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA4 P22748 1/20 0.48
CA7 P43166 1/20 0.48
HDAC8 Q9BY41 1/20 0.47
PKM P14618 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2267959 0.88 PLK1 (0.65) MEN1KMT2ATDP1MAPTRAB9A
SCHEMBL2275929 0.86 KMT2A (0.62) MEN1KMT2ATDP1MAPTPLK1
SCHEMBL2273979 0.85 ALDH1A1 (0.58) MEN1KMT2ATDP1MAPTLMNA
SCHEMBL2274146 0.85 PLK1 (0.56) MEN1KMT2ATDP1MAPTPLK1
SCHEMBL2271421 0.84 DHODH (0.63) MEN1KMT2ATDP1MAPTRAB9A
SCHEMBL2270925 0.84 PLK1 (0.57) MEN1KMT2ATDP1MAPTPLK1
SCHEMBL2276177 0.84 SLC16A3 (0.55) PLK1PLK3ALDH1A1KDM4E
SCHEMBL2270227 0.83 SLC16A3 (0.58) MEN1KMT2ATDP1MAPTRAB9A
SCHEMBL2276254 0.83 CA12 (0.48) MEN1KMT2ATDP1MAPTPLK1
SCHEMBL2274700 0.82 MEN1 (0.55) MEN1KMT2ATDP1MAPTPLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885TDP1 3823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.