SCHEMBL2272111

SCHEMBL2272111

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1cccc(-c2ccccc2)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SUCNR1 Q9BXA5 2/20 0.59
SERPINE1 P05121 1/20 0.57
ACLY P53396 2/20 0.55
MEN1 O00255 2/20 0.55
PKM P14618 2/20 0.55
KMT2A Q03164 2/20 0.55
NR1H4 Q96RI1 3/20 0.53
EPHX2 P34913 1/20 0.51
HCAR2 Q8TDS4 4/20 0.50
LTC4S Q16873 1/20 0.50
MAPT P10636 1/20 0.50
GRIK1 P39086 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
DHODH Q02127 1/20 0.50
CFD P00746 1/20 0.49
F11 P03951 1/20 0.49
TPSB2 P20231 1/20 0.49
PPARG P37231 1/20 0.49
PPARA Q07869 1/20 0.49
MCL1 Q07820 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271421 0.90 DHODH (0.63) SERPINE1ACLYMEN1PKMKMT2A
SCHEMBL2275929 0.90 KMT2A (0.62) ACLYMEN1PKMKMT2ALTC4S
SCHEMBL2275745 0.86 NPC1 (0.56) MEN1PKMKMT2AHCAR2LTC4S
SCHEMBL2273138 0.86 GRIK1 (0.59) SUCNR1SERPINE1ACLYMEN1PKM
SCHEMBL2273979 0.86 ALDH1A1 (0.58) MEN1PKMKMT2AHCAR2LTC4S
SCHEMBL2275720 0.85 SUCNR1 (0.73) SUCNR1SERPINE1ACLYMEN1PKM
SCHEMBL2271236 0.84 PLK1 (0.60) MEN1PKMKMT2ALTC4SMAPT
SCHEMBL2272409 0.84 PLK1 (0.63) MEN1PKMKMT2ALTC4SMAPT
SCHEMBL2270805 0.83 LMNA (0.56) ACLYMEN1PKMKMT2ANR1H4
SCHEMBL2278451 0.83 LTC4S (0.60) SERPINE1MEN1PKMKMT2AHCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SUCNR1 637/4885SERPINE1 101/4885ACLY 653/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.