SCHEMBL2275745

SCHEMBL2275745

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1cccc(F)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.56
MEN1 O00255 5/20 0.53
KMT2A Q03164 5/20 0.53
PKM P14618 2/20 0.53
KCNK3 O14649 1/20 0.51
MAPT P10636 3/20 0.51
POLB P06746 2/20 0.51
CRHBP P24387 1/20 0.51
CRHR2 Q13324 1/20 0.51
TDP1 Q9NUW8 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
HCAR2 Q8TDS4 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
RAB9A P51151 3/20 0.49
LTC4S Q16873 1/20 0.49
GRIK1 P39086 2/20 0.49
NFKB1 P19838 1/20 0.48
NFKB2 Q00653 1/20 0.48
RELA Q04206 1/20 0.48
MCL1 Q07820 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270587 0.90 LTC4S (0.48) NPC1MEN1KMT2APKMMAPT
SCHEMBL2271080 0.89 MEN1 (0.56) NPC1MEN1KMT2APKMKCNK3
SCHEMBL2275929 0.88 KMT2A (0.62) MEN1KMT2APKMMAPTTDP1
SCHEMBL2271933 0.88 MEN1 (0.54) NPC1MEN1KMT2APKMMAPT
SCHEMBL2272111 0.86 SUCNR1 (0.59) MEN1KMT2APKMMAPTTDP1
SCHEMBL2276254 0.85 CA12 (0.48) MEN1KMT2APKMMAPTTDP1
SCHEMBL2273979 0.85 ALDH1A1 (0.58) NPC1MEN1KMT2APKMKCNK3
SCHEMBL2273138 0.85 GRIK1 (0.59) MEN1KMT2APKMKCNK3MAPT
SCHEMBL2270145 0.85 KMT2A (0.55) MEN1KMT2APKMMAPTTDP1
SCHEMBL2273479 0.85 NPC1 (0.53) NPC1MEN1KMT2APKMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 NPC1 4836/4885MEN1 3105/4885KMT2A 1669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.