SCHEMBL2274028

SCHEMBL2274028

O=C(Nc1cc(-n2ccc3ccccc32)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 3/20 0.52
KMT2A Q03164 3/20 0.52
MEN1 O00255 2/20 0.52
GRIK1 P39086 2/20 0.52
MAPT P10636 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
LTC4S Q16873 1/20 0.46
PYGL P06737 1/20 0.46
PYGM P11217 1/20 0.46
PDE11A Q9HCR9 1/20 0.45
PDE10A Q9Y233 1/20 0.45
KDM4D Q6B0I6 1/20 0.44
KDM4C Q9H3R0 1/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SERPINE1 P05121 3/20 0.43
DHODH Q02127 1/20 0.43
ACLY P53396 1/20 0.43
F10 P00742 2/20 0.42
F9 P00740 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14428468 0.91 MEN1 (0.44) PKMKMT2AMEN1GRIK1MAPT
SCHEMBL2273129 0.85 PDE11A (0.41) PKMKMT2AMEN1GRIK1MAPT
SCHEMBL27716722 0.83 ALDH1A1 (0.41) PKMKMT2AMEN1GRIK1MAPT
SCHEMBL28604507 0.83 KDM4E (0.48) KMT2AMEN1MAPTNPC1RAB9A
SCHEMBL14428241 0.81 TOP1 (0.47) KMT2AMEN1MAPTF10F9
SCHEMBL2276731 0.80 MEN1 (0.51) PKMKMT2AMEN1GRIK1MAPT
SCHEMBL2273168 0.79 SERPINE1 (0.61) PKMKMT2AMEN1GRIK1MAPT
Hydrochloric Acid SCHEMBL2270944 0.79 FGFR1 (0.50) PKMKMT2AMEN1GRIK1MAPT
SCHEMBL4215729 0.78 MAPT (0.45) GRIK1MAPTDHODHCYP1A2CYP3A4
SCHEMBL1356949 0.76 PLA2G10 (0.54) KMT2AMEN1MAPTTDP1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PKM 2367/4885KMT2A 1669/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.