SCHEMBL2275605

SCHEMBL2275605

CC(C)(C)OC(=O)c1ccc(-c2cccc(Cl)c2)cc1NC(=O)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 2/20 0.53
MAPT P10636 1/20 0.49
SERPINE1 P05121 2/20 0.49
SUCNR1 Q9BXA5 1/20 0.48
HDAC1 Q13547 3/20 0.48
HSP90AA1 P07900 1/20 0.47
HSP90AB1 P08238 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
KDM4E B2RXH2 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
HDAC2 Q92769 5/20 0.47
PPARG P37231 1/20 0.47
NR1H4 Q96RI1 1/20 0.47
HDAC3 O15379 1/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272448 0.90 CYP1A2 (0.47) ACLYSERPINE1HDAC1MEN1KMT2A
SCHEMBL27696987 0.89 ACLY (0.51) ACLYMAPTSERPINE1SUCNR1HDAC1
SCHEMBL2273488 0.89 SUCNR1 (0.52) ACLYSERPINE1SUCNR1HDAC1MEN1
SCHEMBL2273074 0.86 HDAC1 (0.52) ACLYMAPTHDAC1KDM4EHDAC2
SCHEMBL2268169 0.86 HDAC1 (0.47) ACLYMAPTHDAC1MEN1KMT2A
SCHEMBL2273011 0.86 HDAC1 (0.52) ACLYHDAC1KDM4EHDAC2HDAC3
Cyanate SCHEMBL27830146 0.85 HDAC2 (0.51) ACLYHDAC1KDM4EHDAC2HDAC3
SCHEMBL2274754 0.85 HDAC2 (0.53) ACLYMAPTHDAC1MEN1KMT2A
SCHEMBL2275293 0.84 SNCA (0.45) MAPTMEN1KMT2AKDM4ENPSR1
SCHEMBL2275290 0.84 SNCA (0.45) MAPTMEN1KMT2AKDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ACLY 653/4885MAPT 4824/4885SERPINE1 101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.