Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GGT1 | P19440 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL7521199 | 1.00 | KDM4E (0.52) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Aspirin SCHEMBL28967260 | 0.91 | KDM4E (0.55) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Arginine SCHEMBL27381977 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TDP1KMT2APRSS1TMPRSS15 | |
| Aspirin SCHEMBL2993829 | 0.83 | KDM4E (0.61) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Aspirin SCHEMBL2993825 | 0.83 | KDM4E (0.61) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| SCHEMBL27711307 | 0.82 | KDM4E (0.48) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Arginine SCHEMBL4208935 | 0.82 | ALDH1A1 (0.45) | KDM4EHSD17B10HPGDALDH1A1HMGB1 | |
| Arginine SCHEMBL5606089 | 0.82 | ALDH1A1 (0.45) | KDM4EHSD17B10HPGDALDH1A1HMGB1 | |
| Arginine SCHEMBL2485034 | 0.82 | OTC (0.40) | TDP1KMT2AHTT | |
| Arginine SCHEMBL4728793 | 0.82 | OTC (0.40) | TDP1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115607516-A | Medicine for preventing and treating cold or viral diseases | 刘力 | 2023-01-17 | — | — | CN | claimed |
| CN-115607556-A | Medicine for preventing and treating asthma, chronic obstructive pulmonary disease, allergic diseases, etc | 刘力 | 2023-01-17 | — | — | CN | claimed |
| CN-110141760-B | Centrum forming expansion balloon with drug loaded on surface and preparation method thereof | 山东百多安医疗器械股份有限公司 | 2021-10-08 | — | — | CN | claimed |
| WO-2020244388-A1 | SURFACE-DRUG-LOADING INFLATABLE BALLOON FOR VERTEBROPLASTY AND PREPARATION METHOD THEREFOR | 山东百多安医疗器械股份有限公司 | 2020-12-10 | — | — | WO | claimed |
| CN-111202842-A | Pharmaceutical composition for treating hyaluronic acid vascular embolism | 刘怡 | 2020-05-29 | — | — | CN | claimed |
| CN-106491465-A | A kind of environmental health nutrition type hair growth agent and preparation method thereof | 郑州兰茜生物工程有限公司 | 2017-03-15 | — | — | CN | claimed |
| CN-106420399-A | Laser cosmetology nursing agent, preparation and use method thereof | 河南工业大学 | 2017-02-22 | — | — | CN | claimed |
| CN-106420491-A | Multifunctional skin care product with effects of whitening skin, removing freckles, preserving moisture and removing wrinkle and preparation method of multifunctional skin care product | 郑州兰茜生物工程有限公司 | 2017-02-22 | — | — | CN | claimed |
| CN-105399647-A | Method for preparing arginine aspirin | BENGBU BBCA MEDICINE SCIENCE & DEV CO LTD | 2016-03-16 | — | — | CN | claimed |
| CN-102146030-A | Method for preparing argine asprine | BENGBU BBCA MEDICINE SCIENCE DEV CO LTD | 2011-08-10 | — | — | CN | claimed |
| CN-102098914-A | Novel compositions and methods for treating hyperproliferative diseases | ALS MOUNTAIN LLC | 2011-06-15 | — | — | CN | claimed |
| CN-101704766-A | Preparation method of arginine aspirin and powder-injection of arginine aspirin | ANHUI BBCA PHARMACEUTICAL CO L | 2010-05-12 | — | — | CN | claimed |
| CN-1157201-C | Composite non-opium medicine for dropping drugs | 卢正堂 | 2004-07-14 | — | — | CN | claimed |
| CN-1313108-A | Composite non-opium medicine for dropping drugs | LU ZHENGTANG (CN) | 2001-09-19 | — | — | CN | claimed |
| CN-1226820-A | Cosmetic composition | PROCTER & GAMBLE (US) | 1999-08-25 | — | — | CN | claimed |
| CN-116621689-A | L-lysine-biphenyl acetate, and preparation method and application thereof | 山东省药学科学院 | 2023-08-22 | — | — | CN | disclosed |
| US-20230132582-A1 | NOVEL USE OF ASPIRIN COMPOUND IN INCREASING NUCLEIC ACID EXPRESSION | SHANGHAI BELIEF-DELIVERY BIOMED CO., LTD. (CN) | 2023-05-04 | — | — | US | disclosed |
| CN-1124844-C | Stable lyophilized pharmaceutical preparation | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | CN | disclosed |
| CN-1313108-A | Composite non-opium medicine for dropping drugs | LU ZHENGTANG (CN) | 2001-09-19 | — | — | CN | disclosed |
| CN-1203527-A | Stable freeze-dried pharmaceutical formulation | SANOFI SA (FR) | 1998-12-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132582-A1 | NOVEL USE OF ASPIRIN COMPOUND IN INCREASING NUCLEIC ACID EXPRESSION | NSUN2, DDX21, SNRPE | PTGS1 259/4885PTGS2 270/4885KDM4E 4402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.