Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GGT1 | P19440 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL22747798 | 1.00 | KDM4E (0.52) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Aspirin SCHEMBL28967260 | 0.91 | KDM4E (0.55) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Arginine SCHEMBL27381977 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TDP1KMT2APRSS1TMPRSS15 | |
| Aspirin SCHEMBL2993829 | 0.83 | KDM4E (0.61) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Aspirin SCHEMBL2993825 | 0.83 | KDM4E (0.61) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| SCHEMBL27711307 | 0.82 | KDM4E (0.48) | KDM4EHSD17B10HPGDALDH1A1ESR1 | |
| Arginine SCHEMBL4208935 | 0.82 | ALDH1A1 (0.45) | KDM4EHSD17B10HPGDALDH1A1HMGB1 | |
| Arginine SCHEMBL5606089 | 0.82 | ALDH1A1 (0.45) | KDM4EHSD17B10HPGDALDH1A1HMGB1 | |
| Arginine SCHEMBL2485034 | 0.82 | OTC (0.40) | TDP1KMT2AHTT | |
| Arginine SCHEMBL4728793 | 0.82 | OTC (0.40) | TDP1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102098914-A | Novel compositions and methods for treating hyperproliferative diseases | ALS MOUNTAIN LLC | 2011-06-15 | — | — | CN | claimed |
| EP-0858325-B1 | STABLE FREEZE-DRIED PHARMACEUTICAL FORMULATION | SANOFI SYNTHELABO (FR) | 2002-07-31 | — | — | EP | claimed |
| EP-0936899-A4 | COSMETIC COMPOSITIONS | PROCTER & GAMBLE (US) | 2002-01-02 | — | — | EP | claimed |
| US-6284277-B1 | NONPROTEIN | SANOFI-SYNTHELABO (FR) | 2001-09-04 | — | — | US | claimed |
| US-6267978-B1 | COSMETIC FOR REGULATION OF THE OILY AND/OR SHINY APPEARANCE OF SKIN | THE PROCTER & GAMBLE COMPANY | 2001-07-31 | — | — | US | claimed |
| US-6143310-A | WATER IN OIL EMULSION CONTAINING AMINO ACID SALT OF SALICYLIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-07 | — | — | US | claimed |
| EP-0936899-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1998010741-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-19 | — | — | WO | claimed |
| JP-7330612-A | — | — | None | — | — | JP | disclosed |
| CN-101486644-B | Preparation of arginine acetylsalicylate | UNIV HEFEI TECHNOLOGY | 2012-07-25 | — | — | CN | disclosed |
| CN-102146030-A | Method for preparing argine asprine | BENGBU BBCA MEDICINE SCIENCE DEV CO LTD | 2011-08-10 | — | — | CN | disclosed |
| CN-102098914-A | Novel compositions and methods for treating hyperproliferative diseases | ALS MOUNTAIN LLC | 2011-06-15 | — | — | CN | disclosed |
| CN-101486644-A | Preparation of arginine acetylsalicylate | UNIV HEFEI TECHNOLOGY (CN) | 2009-07-22 | — | — | CN | disclosed |
| US-6284277-B1 | NONPROTEIN | SANOFI-SYNTHELABO (FR) | 2001-09-04 | — | — | US | disclosed |
| JP-H07330612-A | POWDERY PREPARATION CONTAINING METOCLOPRAMIDE AND PARACETAMOL OR ITS ACETYLSALICYLIC ACID DERIVATIVE | SYNTHELABO SA | 1995-12-19 | — | — | JP | disclosed |