Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL20702218 | 0.87 | NPY4R (0.40) | L3MBTL1EGLN2LTA4HSLC1A3OTC | |
| Aspirin SCHEMBL7521199 | 0.85 | KDM4E (0.52) | ALDH1A1MAPTKMT2ATDP1PRSS1 | |
| Aspirin SCHEMBL22747798 | 0.85 | KDM4E (0.52) | ALDH1A1MAPTKMT2ATDP1PRSS1 | |
| SCHEMBL7780233 | 0.85 | NPY4R (0.40) | L3MBTL1SIRT1EGLN2LTA4HSLC1A3 | |
| SCHEMBL7780232 | 0.85 | NPY4R (0.40) | L3MBTL1SIRT1EGLN2LTA4HSLC1A3 | |
| Arginine SCHEMBL19283975 | 0.83 | FNTA (0.41) | EGLN2 | |
| Lactic Acid SCHEMBL20702219 | 0.83 | NPY4R (0.40) | GAAL3MBTL1EGLN2LTA4HSLC1A3 | |
| Arginine SCHEMBL16879777 | 0.83 | KIF11 (0.47) | OTCNOS3NOS1NOS2POLB | |
| Arginine SCHEMBL28268971 | 0.83 | OTC (0.53) | OTCNOS3NOS1NOS2KMT2A | |
| Arginine SCHEMBL1401438 | 0.82 | SLC7A5 (0.59) | LTA4HSLC1A3OTCANPEPRNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1069736-A | New isosteric peptides | ASTRA AB (SE) | 1993-03-10 | — | — | CN | disclosed |