SCHEMBL2275565

SCHEMBL2275565

COc1cccc(C=Cc2ccc(C(=O)O)c(NC(=O)C3=COC(Cc4ccccc4)O3)c2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRSS12 P56730 1/20 0.41
ACHE P22303 2/20 0.40
SNCA P37840 1/20 0.39
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 1/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 2/20 0.38
BCHE P06276 2/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
GRIK1 P39086 1/20 0.38
PYGM P11217 1/20 0.37
AKR1C3 P42330 1/20 0.37
AKR1C2 P52895 1/20 0.37
MEN1 O00255 1/20 0.37
NPC1 O15118 1/20 0.37
TRPA1 O75762 1/20 0.37
MAPT P10636 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2267869 0.81 CYP2C9 (0.45) PRSS12PYGMMAPTKMT2ASMN1; SMN2
SCHEMBL2271828 0.78 SNCA (0.61) SNCARAB9ABCHEGRIK1PYGM
SCHEMBL2271821 0.78 SNCA (0.61) SNCARAB9ABCHEGRIK1PYGM
SCHEMBL2272547 0.78 ACLY (0.40) PRSS12ALDH1A1RAB9ANPC1L3MBTL1
SCHEMBL2278113 0.77 NPC1 (0.39) PRSS12ALDH1A1RAB9AGRIK1MEN1
SCHEMBL2276077 0.77 PRSS12 (0.43) PRSS12SNCAGRIK1MEN1MAPT
SCHEMBL2277761 0.75 ACLY (0.44) PRSS12HCAR2
SCHEMBL2274220 0.75 ACLY (0.49) GRIK1HCAR2
SCHEMBL2270270 0.73 MEN1 (0.67) ACHEALDH1A1KDM4ERAB9ABCHE
SCHEMBL2270274 0.73 MEN1 (0.67) ACHEALDH1A1KDM4ERAB9ABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PRSS12 1133/4885ACHE 3499/4885SNCA 4741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.