SCHEMBL2276077

SCHEMBL2276077

O=C(Nc1cc(C=CC2=COC(Cc3ccccc3)O2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PRSS12 P56730 2/20 0.43
MEN1 O00255 2/20 0.43
PKM P14618 2/20 0.43
KMT2A Q03164 2/20 0.43
GRIK1 P39086 2/20 0.43
MAPT P10636 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
LTC4S Q16873 1/20 0.41
SNCA P37840 7/20 0.39
MCL1 Q07820 1/20 0.39
BCL2A1 Q16548 1/20 0.39
PTPN1 P18031 1/20 0.37
KDM4D Q6B0I6 1/20 0.37
KDM4C Q9H3R0 1/20 0.37
ACLY P53396 1/20 0.36
DHODH Q02127 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274797 0.80 MEN1 (0.46) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2276655 0.79 PKM (0.62) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2276651 0.79 PKM (0.62) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2270239 0.77 PYGM (0.46) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2275565 0.77 PRSS12 (0.41) PRSS12MEN1KMT2AGRIK1MAPT
SCHEMBL2270230 0.76 KMT2A (0.57) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2270237 0.76 KMT2A (0.57) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2276918 0.75 SNCA (0.66) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2276923 0.75 SNCA (0.66) MEN1PKMKMT2AGRIK1MAPT
SCHEMBL2272929 0.74 KMT2A (0.55) MEN1PKMKMT2AGRIK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PRSS12 1133/4885MEN1 3105/4885PKM 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.