Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.43 |
| ▸ | EDNRB | P24530 | 6/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760072 | 0.85 | EDNRA (0.41) | EDNRAEDNRBPTGS1PTGS2 | |
| SCHEMBL22760375 | 0.82 | NOTUM (0.37) | TSHRSMN1; SMN2 | |
| SCHEMBL22760346 | 0.81 | FOLH1 (0.45) | EDNRAMAPK8TSHR | |
| SCHEMBL22760073 | 0.81 | CENPE (0.39) | MAPK8SMN1; SMN2 | |
| SCHEMBL22760140 | 0.81 | NOTUM (0.41) | EDNRAMAPK8TSHR | |
| SCHEMBL22760373 | 0.80 | FOLH1 (0.36) | MAPK8 | |
| SCHEMBL22760067 | 0.79 | EDNRA (0.41) | EDNRAEDNRBMAPK8 | |
| SCHEMBL22760103 | 0.78 | NPSR1 (0.45) | EDNRAEDNRBTSHRHPGDSMN1; SMN2 | |
| SCHEMBL22760374 | 0.78 | HTT (0.33) | HPGD | |
| SCHEMBL22747838 | 0.77 | NOTUM (0.42) | EDNRAEDNRBMAPK8TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |