Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482164 | 0.92 | P2RX7 (0.35) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL6505938 | 0.89 | KMT2A (0.37) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL143633 | 0.85 | GHSR (0.34) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL30713527 | 0.81 | EPHX2 (0.38) | MEN1KMT2AMAPK1 | |
| SCHEMBL19177379 | 0.80 | CTSK (0.35) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL144836 | 0.79 | MEN1 (0.39) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL142219 | 0.79 | MEN1 (0.39) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL5110550 | 0.79 | GHSR (0.33) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL2051406 | 0.79 | GHSR (0.33) | MEN1KMT2AMAPK1GHSRCTSL | |
| SCHEMBL21132654 | 0.78 | MEN1 (0.37) | MEN1KMT2AMAPK1GHSRCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174224-B2 | Cathepsin inhibitors | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2021-11-16 | — | — | US | disclosed |
| US-20200385341-A1 | CATHEPSIN INHIBITORS | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) | 2020-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385341-A1 | CATHEPSIN INHIBITORS | CTSK, CTSZ, CTSF | MEN1 4333/4885KMT2A 3694/4885MAPK1 3538/4885 |
| US-11174224-B2 | Cathepsin inhibitors | CTSK, CTSZ, CTSF | MEN1 4333/4885KMT2A 3694/4885MAPK1 3538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.