SCHEMBL2276799

SCHEMBL2276799

O=C(Nc1cc(N2CCC(Cc3ccccc3)CC2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 1/20 0.52
PRSS12 P56730 2/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
MAPT P10636 3/20 0.50
LMNA P02545 2/20 0.50
CCR3 P51677 1/20 0.47
PKM P14618 1/20 0.47
GRIK1 P39086 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
HDAC6 Q9UBN7 2/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
FAAH O00519 1/20 0.46
BRCA1 P38398 1/20 0.45
LTC4S Q16873 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270309 0.83 PKM (0.50) MALT1SMN1; SMN2MEN1KMT2AMAPT
SCHEMBL2275234 0.83 MALT1 (0.51) MALT1PRSS12SMN1; SMN2MEN1KMT2A
SCHEMBL2952169 0.76 MEN1 (0.65) MEN1KMT2AMAPT
SCHEMBL2273832 0.74 PPARG (0.54) SMN1; SMN2MEN1KMT2AMAPTLMNA
SCHEMBL6429862 0.74 GAA (0.60) SMN1; SMN2MAPTBRCA1
SCHEMBL846605 0.74 BCHE (0.71)
SCHEMBL846604 0.74 KDR (0.58) SMN1; SMN2MEN1KMT2AMAPTFAAH
SCHEMBL5889215 0.73 ALDH1A1 (0.58) SMN1; SMN2MEN1KMT2AMAPTLMNA
SCHEMBL28332101 0.73 AKR1C3 (0.45) MALT1MAPT
SCHEMBL2268310 0.72 MAPT (0.48) SMN1; SMN2MEN1KMT2AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MALT1 3359/4885PRSS12 1133/4885SMN1; SMN2 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.