SCHEMBL2268310

SCHEMBL2268310

O=C(Nc1cc(N2CC=C(c3ccccc3)CC2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.48
MEN1 O00255 2/20 0.48
PKM P14618 2/20 0.48
KMT2A Q03164 2/20 0.48
GRIK1 P39086 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
DHODH Q02127 1/20 0.45
ACLY P53396 1/20 0.45
SIGMAR1 Q99720 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 2/20 0.42
TSHR P16473 2/20 0.42
PLA2G1B P04054 1/20 0.42
ATG4B Q9Y4P1 1/20 0.42
NPC1 O15118 1/20 0.42
ALOX15 P16050 1/20 0.42
RAB9A P51151 1/20 0.42
SERPINE1 P05121 3/20 0.42
KDM4D Q6B0I6 1/20 0.41
KDM4C Q9H3R0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273832 0.80 PPARG (0.54) MAPTMEN1PKMKMT2AGRIK1
SCHEMBL2270309 0.75 PKM (0.50) MAPTMEN1PKMKMT2AGRIK1
SCHEMBL2275234 0.75 MALT1 (0.51) MAPTMEN1PKMKMT2AGRIK1
SCHEMBL2273168 0.73 SERPINE1 (0.61) MAPTMEN1PKMKMT2AGRIK1
SCHEMBL2269025 0.73 MAPT (0.50) MAPTMEN1PKMKMT2AGRIK1
SCHEMBL2276799 0.72 MALT1 (0.52) MAPTMEN1PKMKMT2AGRIK1
SCHEMBL2275453 0.72 ACLY (0.76) MAPTMEN1PKMKMT2AGRIK1
SCHEMBL2272642 0.72 HDAC1 (0.59) MAPTMEN1KMT2ADHODHACLY
SCHEMBL12118163 0.71 HDAC1 (0.52) MAPTMEN1PKMKMT2ADHODH
SCHEMBL1315559 0.70 HDAC1 (0.51) MAPTMEN1PKMKMT2ADHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MAPT 4824/4885MEN1 3105/4885PKM 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.