SCHEMBL2276941

SCHEMBL2276941

O=C(Nc1cc(-c2cccc(OC(F)(F)F)c2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
IGF2BP2 Q9Y6M1 1/20 0.68
ACLY P53396 2/20 0.55
DHODH Q02127 8/20 0.54
HDAC2 Q92769 2/20 0.54
KCNK2 O95069 1/20 0.54
KCNK10 P57789 1/20 0.54
SUCNR1 Q9BXA5 1/20 0.50
MEN1 O00255 1/20 0.50
MAPT P10636 1/20 0.50
PKM P14618 1/20 0.50
GRIK1 P39086 1/20 0.50
KMT2A Q03164 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
HDAC6 Q9UBN7 1/20 0.49
HDAC1 Q13547 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272429 0.91 IGF2BP2 (0.71) IGF2BP2ACLYDHODHHDAC2KCNK2
SCHEMBL1317577 0.87 IGF2BP2 (0.58) IGF2BP2ACLYDHODHKCNK2KCNK10
SCHEMBL2269841 0.86 IGF2BP2 (0.61) IGF2BP2KCNK2KCNK10MEN1MAPT
SCHEMBL2271137 0.84 HDAC2 (0.74) ACLYDHODHHDAC2KCNK2KCNK10
SCHEMBL2275453 0.82 ACLY (0.76) ACLYDHODHHDAC2SUCNR1MEN1
SCHEMBL2275504 0.81 IGF2BP2 (0.56) IGF2BP2ACLYDHODHHDAC2KCNK2
SCHEMBL2274009 0.81 IGF2BP2 (0.61) IGF2BP2KCNK2KCNK10MEN1MAPT
SCHEMBL2271280 0.80 ACLY (0.62) ACLYDHODHHDAC2SUCNR1MEN1
SCHEMBL2272033 0.80 ACLY (0.62) ACLYDHODHHDAC2MEN1MAPT
SCHEMBL4215780 0.80 IGF2BP2 (0.57) IGF2BP2ACLYDHODHTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 IGF2BP2 4173/4885ACLY 653/4885DHODH 1469/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.