SCHEMBL1317577

SCHEMBL1317577

O=C(Nc1cc(-c2cccc(OC(F)(F)F)c2)ccc1C(=O)O)c1cncc(-c2ccccc2)c1.[NaH]

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
IGF2BP2 Q9Y6M1 1/20 0.58
ABL1 P00519 6/20 0.52
SCN10A Q9Y5Y9 1/20 0.52
OPRM1 P35372 1/20 0.52
KCNH2 Q12809 1/20 0.52
ACLY P53396 2/20 0.50
DHODH Q02127 6/20 0.47
KDM5A P29375 1/20 0.47
KDM4C Q9H3R0 1/20 0.47
KDM5B Q9UGL1 1/20 0.47
KCNK2 O95069 1/20 0.46
KCNK10 P57789 1/20 0.46
SUCNR1 Q9BXA5 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317574 0.91 DHODH (0.52) IGF2BP2ABL1SCN10AOPRM1KCNH2
SCHEMBL1318104 0.89 ACLY (0.50) IGF2BP2ACLYDHODHSUCNR1
SCHEMBL1315613 0.87 HDAC2 (0.56) ACLYDHODHSUCNR1
SCHEMBL2276941 0.87 IGF2BP2 (0.68) IGF2BP2ACLYDHODHKCNK2KCNK10
SCHEMBL1316613 0.86 SCN10A (0.49) IGF2BP2ABL1SCN10AOPRM1KCNH2
SCHEMBL1315751 0.85 ACLY (0.64) ACLYDHODHKDM4CSUCNR1
SCHEMBL1319354 0.85 RXRA (0.54) ACLYDHODHSUCNR1
SCHEMBL1316878 0.85 ACLY (0.60) ACLYSUCNR1
SCHEMBL1317101 0.84 ACLY (0.51) IGF2BP2ABL1SCN10AOPRM1KCNH2
SCHEMBL15127677 0.83 ACLY (0.52) IGF2BP2ABL1SCN10AOPRM1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 IGF2BP2 3771/4885ABL1 849/4885SCN10A 820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.